CAJ | 학술논문

目的：比较三餐前短效+睡前中效胰岛素(诺和灵R+诺和灵N)和三餐前速效和中效的预混胰岛素(诺和锐30)的两种胰岛素强化治疗方案在2型糖尿病合并心肌梗塞患者中的疗效及安全性。方法将41例入选患者随机分成2组，比较两组患者治疗前后血糖达标时间、胰岛素用量、低血糖发生率。结果三餐前注射诺和锐30和三餐前注射诺和灵R +睡前注射诺和灵N这两种方案的达标时间分别为16.6±5.2天和15.4±4.1天(P>0.05)，低血糖发生率为9.5%和19.04%(P<0.05)，日均胰岛素使用量为50.5±6.1U和55.2±6.8U(P<0.05)。结论对于2型糖尿病合并心肌梗塞患者，三餐前速效和中效的预混胰岛素的方案相比三餐前短效+睡前中效胰岛素的方案低血糖发生率低，胰岛素总剂量相对较小，病人使用的依从性强。
목적：비교삼찬전단효+수전중효이도소(낙화령R+낙화령N)화삼찬전속효화중효적예혼이도소(낙화예30)적량충이도소강화치료방안재2형당뇨병합병심기경새환자중적료효급안전성。방법장41례입선환자수궤분성2조，비교량조환자치료전후혈당체표시간、이도소용량、저혈당발생솔。결과삼찬전주사낙화예30화삼찬전주사낙화령R +수전주사낙화령N저량충방안적체표시간분별위16.6±5.2천화15.4±4.1천(P>0.05)，저혈당발생솔위9.5%화19.04%(P<0.05)，일균이도소사용량위50.5±6.1U화55.2±6.8U(P<0.05)。결론대우2형당뇨병합병심기경새환자，삼찬전속효화중효적예혼이도소적방안상비삼찬전단효+수전중효이도소적방안저혈당발생솔저，이도소총제량상대교소，병인사용적의종성강。
Objective To compare the efifcacy andsafety of two kinds of intensive insulin therapy in type 2 diabetes patients with myocardial infarction: thrice preprandial injection of insulin Novolin R and injection of Novolin N at bedtime; thrice preprandial injection of premixed insulin aspart 30.Methods The 41 cases selected patients were randomly divided into two groups, compare the blood glucose level, therapeutic time, dosage of insulin and occurrence of hypoglycemia. Results Compare to thrice preprandial injection of insulin Novolin R and injection of Novolin N at bedtime; thrice preprandial injection of insulin aspart 30; the time for blood glucose control were (16.6±5.2)d and (15.4±4.1)d, P>0.05;occurrence of hypoglycemia were 9.5% and 19.04%, P<0.05; dosage of insulin were (50.5±6.1)U and (55.2±6.8) U, P<0.05.Conclusion For type 2 diabetes patients with myocardial infarction, the treatment of thrice preprandial injection of premixed insulin aspart 30 compare to the treatment of thrice preprandial injection of insulin Novolin R and injection of Novolin N at bedtime is less occurrence of hypoglycemia, small total insulin dose, more patient compliance.