中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2015年
7期
32-35
,共4页
路志术%曾江琴%余芳%孙勤国
路誌術%曾江琴%餘芳%孫勤國
로지술%증강금%여방%손근국
高血压病%加味温胆汤%痰湿体质%血管内皮生长因子
高血壓病%加味溫膽湯%痰濕體質%血管內皮生長因子
고혈압병%가미온담탕%담습체질%혈관내피생장인자
hypertension%modified Wendan Decoction%phlegm-damp constitution%VEGF
目的：观察加味温胆汤结合氨氯地平片治疗痰湿体质高血压患者临床疗效及其对患者体质和血管内皮生长因子(VEGF)的影响。方法将126例患者随机分为治疗组和对照组各63例,治疗组予加味温胆汤结合氨氯地平片,对照组仅予氨氯地平片,疗程均为12周。观察2组患者治疗前后血压、中医痰湿质评分及血清VEGF水平,比较2组降压疗效。结果治疗组治疗后中医痰湿质评分较治疗前明显降低(P＜0.01),对照组中医痰湿质评分与治疗前差异无统计学意义(P＞0.05),治疗组优于对照组(P＜0.01)；2组治疗后收缩压、舒张压、血清 VEGF水平较治疗前均明显下降(P＜0.01),治疗组优于对照组(P＜0.05)；治疗组、对照组降压总有效率分别为92.1%(58/63)、76.2%(48/63),2组比较差异有统计学意义(P＜0.05)。结论加味温胆汤结合氨氯地平片可明显改善痰湿体质高血压患者的偏颇体质,降低血清VEGF水平,改善血管内皮功能,降压疗效显著。
目的：觀察加味溫膽湯結閤氨氯地平片治療痰濕體質高血壓患者臨床療效及其對患者體質和血管內皮生長因子(VEGF)的影響。方法將126例患者隨機分為治療組和對照組各63例,治療組予加味溫膽湯結閤氨氯地平片,對照組僅予氨氯地平片,療程均為12週。觀察2組患者治療前後血壓、中醫痰濕質評分及血清VEGF水平,比較2組降壓療效。結果治療組治療後中醫痰濕質評分較治療前明顯降低(P＜0.01),對照組中醫痰濕質評分與治療前差異無統計學意義(P＞0.05),治療組優于對照組(P＜0.01)；2組治療後收縮壓、舒張壓、血清 VEGF水平較治療前均明顯下降(P＜0.01),治療組優于對照組(P＜0.05)；治療組、對照組降壓總有效率分彆為92.1%(58/63)、76.2%(48/63),2組比較差異有統計學意義(P＜0.05)。結論加味溫膽湯結閤氨氯地平片可明顯改善痰濕體質高血壓患者的偏頗體質,降低血清VEGF水平,改善血管內皮功能,降壓療效顯著。
목적：관찰가미온담탕결합안록지평편치료담습체질고혈압환자림상료효급기대환자체질화혈관내피생장인자(VEGF)적영향。방법장126례환자수궤분위치료조화대조조각63례,치료조여가미온담탕결합안록지평편,대조조부여안록지평편,료정균위12주。관찰2조환자치료전후혈압、중의담습질평분급혈청VEGF수평,비교2조강압료효。결과치료조치료후중의담습질평분교치료전명현강저(P＜0.01),대조조중의담습질평분여치료전차이무통계학의의(P＞0.05),치료조우우대조조(P＜0.01)；2조치료후수축압、서장압、혈청 VEGF수평교치료전균명현하강(P＜0.01),치료조우우대조조(P＜0.05)；치료조、대조조강압총유효솔분별위92.1%(58/63)、76.2%(48/63),2조비교차이유통계학의의(P＜0.05)。결론가미온담탕결합안록지평편가명현개선담습체질고혈압환자적편파체질,강저혈청VEGF수평,개선혈관내피공능,강압료효현저。
Objective To observe the clinical efficacy of modified Wendan Decoction combined with amlodipine tablets in treating hypertensive patients with phlegm-damp constitution, and the impact on patients' constitution and vascular endothelial growth factor (VEGF). Methods Totally 126 patients were randomly divided into two groups, 63 cases in each group. The treatment group was given modified Wendan Decoction combined with amlodipine tablets, while the control group received amlodipine tablets, for 12 weeks. The blood pressures, TCM phlegm-damp scores, and serum VEGF levels in both groups were observed before and after treatment. Antihypertensive effect between the two groups was compared. Results TCM phlegm-damp scores decreased significantly in the treatment group after treatment (P<0.01), while that was not significant in the control group (P>0.05). The treatment group was superior to the control group (P<0.01). The systolic blood pressure, diastolic blood pressure, and serum VEGF level significantly decreased after treatment (P<0.01), and the indicators of treatment group were better than those of the control group (P<0.05). The total efficiency of treatment group and control group were 92.1%(58/63) and 76.2%(48/63), respectively, the difference was significant (P<0.05). Conclusion Modified Wendan Decoction combined with amlodipine tablets can significantly improve biased constitution in hypertension patients with phlegm-damp constitution, lower serum VEGF level, and improve endothelial function, with good antihypertensive effect.
