世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2015年
6期
865-868
,共4页
子宫内膜异位症%痛经%蠲痛饮加减%EmAb
子宮內膜異位癥%痛經%蠲痛飲加減%EmAb
자궁내막이위증%통경%견통음가감%EmAb
Endometriosis%Dysmenorrhea%Modified Juantong decoction%EmAb
目的：探讨蠲痛饮加减方治疗子宫内膜异位症痛经的临床疗效及部分机制。方法：将本院2011年4月至2013年11月50例子宫内膜异位症痛经纳入研究，根据入院先后顺序分为观察组和对照组，各25例。对照组予口服孕三烯酮，自月经当天起开始服用，口服2次／周，2．5 mg／次，连续服用12周。观察组在对照组治疗方案的基础上再予口服蠲痛饮加减方，自月经结束第2日起开始服用，2次／d，每次100 mL 温服，连续服用12周。2组患者治疗期间均无服用其他药物。疗程结束后观察2组患者的肝肾功能、痛经程度积分、子宫内膜中子宫内膜抗体（EmAb）的浓度。结果：1）经过药物干预后痛经积分均有所下降，其中观察组下降的幅度更明显（P ＜0．05）；2）蛋白印迹法（Western Blotting）、酶联免疫吸附试验（Elisa）检测 EmAb 水平，发现2组患者子宫内膜的 EmAb 水平均下降，其中观察组患者血清中 EmAb 浓度下降趋势较对照组明显（P ＜0．05）；3）2组均无肝肾功能损害发生。结论：EmAb 升高能够诱发子宫内膜异位症痛经，而蠲痛饮加减方能够通过降低 EmAb 浓度达到治疗子宫内膜异位症痛经的目的。
目的：探討蠲痛飲加減方治療子宮內膜異位癥痛經的臨床療效及部分機製。方法：將本院2011年4月至2013年11月50例子宮內膜異位癥痛經納入研究，根據入院先後順序分為觀察組和對照組，各25例。對照組予口服孕三烯酮，自月經噹天起開始服用，口服2次／週，2．5 mg／次，連續服用12週。觀察組在對照組治療方案的基礎上再予口服蠲痛飲加減方，自月經結束第2日起開始服用，2次／d，每次100 mL 溫服，連續服用12週。2組患者治療期間均無服用其他藥物。療程結束後觀察2組患者的肝腎功能、痛經程度積分、子宮內膜中子宮內膜抗體（EmAb）的濃度。結果：1）經過藥物榦預後痛經積分均有所下降，其中觀察組下降的幅度更明顯（P ＜0．05）；2）蛋白印跡法（Western Blotting）、酶聯免疫吸附試驗（Elisa）檢測 EmAb 水平，髮現2組患者子宮內膜的 EmAb 水平均下降，其中觀察組患者血清中 EmAb 濃度下降趨勢較對照組明顯（P ＜0．05）；3）2組均無肝腎功能損害髮生。結論：EmAb 升高能夠誘髮子宮內膜異位癥痛經，而蠲痛飲加減方能夠通過降低 EmAb 濃度達到治療子宮內膜異位癥痛經的目的。
목적：탐토견통음가감방치료자궁내막이위증통경적림상료효급부분궤제。방법：장본원2011년4월지2013년11월50례자궁내막이위증통경납입연구，근거입원선후순서분위관찰조화대조조，각25례。대조조여구복잉삼희동，자월경당천기개시복용，구복2차／주，2．5 mg／차，련속복용12주。관찰조재대조조치료방안적기출상재여구복견통음가감방，자월경결속제2일기개시복용，2차／d，매차100 mL 온복，련속복용12주。2조환자치료기간균무복용기타약물。료정결속후관찰2조환자적간신공능、통경정도적분、자궁내막중자궁내막항체（EmAb）적농도。결과：1）경과약물간예후통경적분균유소하강，기중관찰조하강적폭도경명현（P ＜0．05）；2）단백인적법（Western Blotting）、매련면역흡부시험（Elisa）검측 EmAb 수평，발현2조환자자궁내막적 EmAb 수평균하강，기중관찰조환자혈청중 EmAb 농도하강추세교대조조명현（P ＜0．05）；3）2조균무간신공능손해발생。결론：EmAb 승고능구유발자궁내막이위증통경，이견통음가감방능구통과강저 EmAb 농도체도치료자궁내막이위증통경적목적。
Objective:To discuss the clinical curative effect and part of its mechanism of modified Juantong decoction for the treat-ment of endometriosis dysmenorrhea.Methods:Fifty cases of patients with endometriosis dysmenorrhea treated in our hospital dur-ing April 201 1 to November 201 3 were included in the study and divided into observation group and control group according to ad-mission order,with 25 cases in each group.Patients in control group received oral gestrinone from the first day of their menstrua-tion,2 times per week,2.5 mg/time,continuously for 1 2 weeks.The observation group had warm modified Juantong decoction a-part from the same treatment as the control group,though from the second day after the menstruation ends,2 times/day,1 00 mL per time,continuously for 1 2 weeks.No other drugs were applied during treatment in both groups.hepatic and renal function,de-gree of dysmenorrhea score,endometrial antibody (EmAb)concentration of endometrial of the two groups of the patients after the treatment were observed.Results:1 )after the drug intervention,dysmenorrhea score decreased,the decrease of observation group was more obvious (P <0.05);2)through Western blotting and Elisa detection of EmAb level,it was found that endometrial Em-Ab level decreased in both of the two groups of patients,the down trend of EmAb serum concentration in the observation group was more significant than the control group (P <0.05);3)both groups had no hepatic and renal function lesion.Conclusion:The in-crease of EmAb can induce endometriosis dysmenorrhea,and modified Juantong decoction can reduce EmAb concentration to treat endometriosis dysmenorrhea.
