世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2015年
6期
862-864,868
,共4页
消银解毒饮%银屑病血热证%T 淋巴细胞%共刺激因子
消銀解毒飲%銀屑病血熱證%T 淋巴細胞%共刺激因子
소은해독음%은설병혈열증%T 림파세포%공자격인자
Xiaoyinjiedu Drink%Blood-heat Syndrome of Ps%T-lymphocytes%Co-stimulatory factor
目的：观察正常人及银屑病患者应用消银解毒饮治疗前后外周血 T 淋巴细胞及共刺激因子表达的变化，探讨“消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用。方法：治疗组给予连续8周消银解毒饮治疗，用流式细胞术检测，与对照组相互比较外周血 T 细胞亚群及共同刺激分子 CD28、CD80、CD86的表达情况。结果：治疗组治疗后皮损评分降低；治疗前后与正常人相比 CD3＋、CD4＋细胞及 CD4＋／CD8＋降低，CD8＋细胞升高；CD28疗前高于、疗后低于正常组；CD86治疗前后均明显高于正常组；CD80正常组与治疗前均无明显统计学意义，治疗后有下降的趋势。治疗组治疗前、后外周血T 细胞亚群 CD3＋、CD4＋、CD8＋、CD4＋／CD8＋和共刺激因子 CD28、CD80、CD86均无明显的统计学意义。结论：消银解毒饮临床疗效肯定；银屑病患者外周血 T 细胞亚群及共刺激因子的表达存在异常；患者临床症状的好转与外周血 T 细胞亚群及共刺激因子表达的改变是否平行相关尚不确定。
目的：觀察正常人及銀屑病患者應用消銀解毒飲治療前後外週血 T 淋巴細胞及共刺激因子錶達的變化，探討“消銀解毒飲”對銀屑病血熱證外週血淋巴細胞調控作用。方法：治療組給予連續8週消銀解毒飲治療，用流式細胞術檢測，與對照組相互比較外週血 T 細胞亞群及共同刺激分子 CD28、CD80、CD86的錶達情況。結果：治療組治療後皮損評分降低；治療前後與正常人相比 CD3＋、CD4＋細胞及 CD4＋／CD8＋降低，CD8＋細胞升高；CD28療前高于、療後低于正常組；CD86治療前後均明顯高于正常組；CD80正常組與治療前均無明顯統計學意義，治療後有下降的趨勢。治療組治療前、後外週血T 細胞亞群 CD3＋、CD4＋、CD8＋、CD4＋／CD8＋和共刺激因子 CD28、CD80、CD86均無明顯的統計學意義。結論：消銀解毒飲臨床療效肯定；銀屑病患者外週血 T 細胞亞群及共刺激因子的錶達存在異常；患者臨床癥狀的好轉與外週血 T 細胞亞群及共刺激因子錶達的改變是否平行相關尚不確定。
목적：관찰정상인급은설병환자응용소은해독음치료전후외주혈 T 림파세포급공자격인자표체적변화，탐토“소은해독음”대은설병혈열증외주혈림파세포조공작용。방법：치료조급여련속8주소은해독음치료，용류식세포술검측，여대조조상호비교외주혈 T 세포아군급공동자격분자 CD28、CD80、CD86적표체정황。결과：치료조치료후피손평분강저；치료전후여정상인상비 CD3＋、CD4＋세포급 CD4＋／CD8＋강저，CD8＋세포승고；CD28료전고우、료후저우정상조；CD86치료전후균명현고우정상조；CD80정상조여치료전균무명현통계학의의，치료후유하강적추세。치료조치료전、후외주혈T 세포아군 CD3＋、CD4＋、CD8＋、CD4＋／CD8＋화공자격인자 CD28、CD80、CD86균무명현적통계학의의。결론：소은해독음림상료효긍정；은설병환자외주혈 T 세포아군급공자격인자적표체존재이상；환자림상증상적호전여외주혈 T 세포아군급공자격인자표체적개변시부평행상관상불학정。
Objective: To explore the regulation role of Xiaoyinjiedu drink on peripheral blood T-lymphocytes in blood-heat syn-drome of Ps(Psoriasis)patients by observing peripheral blood T lymphocytes and the expression of co-stimulatory factor changes of normal and Psoriasis patients,who received Xiaoyinjiedu Drink.Methods:Treatment group was given 8 weeks of medication,using flow cytometry,while comparison was made to the control group in terms of Peripheral Blood T-lymphocytes and Co-stimulatory fac-tor CD28,CD80,CD86.Results:The treatment group’s lesion scores decreased after treatment;CD3 +,CD4 +and CD4 +/CD8 + is reduced when compared with normal group before and after treatment;CD28 was higher than the normal group before treatment, but lower than normal group after treatment;CD86 was significantly higher than the normal group before and after treatment;There was no significant difference between the normal group and treatment before,but after treatment there was a downward trend in CD80.There was no significant difference in the peripheral T-lymphocytes CD3 +,CD4 +,CD8 +,CD4 +/CD8 + and Co-stimula-tory factor CD28,CD80,CD86 before and after treatment in the treatment group.Conclusion:Xiaoyinjiedu Drink has positive clin-ical effect.Psoriasis patients’peripheral blood T-lymphocytes and Co-stimulatory factor have abnormal expression.It is uncertain whether the improvement of clinical symptoms of patients and the expression of T-lymphocytes and Co-stimulatory factor are parallel related.
