临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
12期
987-990
,共4页
涎腺腺样囊性癌%基质金属蛋白酶9%碱性成纤维细胞生长因子
涎腺腺樣囊性癌%基質金屬蛋白酶9%堿性成纖維細胞生長因子
연선선양낭성암%기질금속단백매9%감성성섬유세포생장인자
Salivary adenoid cysticcarcinoma%Matrix metalloproteinases-9%Basic fibroblast growth factor
目的：探究涎腺腺样囊性癌（SACC）患者血清基质金属蛋白酶9（MMP-9）的表达与意义。方法分析2012年1月至2014年12月收治并诊断为SACC病人的临床资料。涎腺细胞受到癌细胞侵袭的病例作为观察组，患有SACC癌旁腺组织正常的病人纳为对照组。观察两组血清MMP-9、基质金属酶抑制因子（ TIMP-1）、碱性成纤维细胞生长因子（ bFGF）水平，及观察组在不同病理参数下上述指标的水平和三项指标间的相关性。结果观察组患者血清中MMP-9、TIMP、bFGF水平明显高于对照组（ P <0.01）。患者的病理分型、淋巴转移、TMN分期差异具有统计学意义（ P <0.01），其中三种指标水平腺管型显著高于实性型，有淋巴转移显著高于无淋巴转移，TMN分期T3~T4高于T1~T2。MMP-9与TIMP-1（ r =0.700，P <0.001）、bFGF（ r =0.799，P <0.001）呈显著的正相关。结论 MMP-9、TIMP-1、bFGF随着SACC患者病理分型、淋巴转移、TMN分期的发展具有协同增高的关系；MMP-9与TIMP-1、bFGF呈显著的正相关。血清中MMP-9、TIMP-1、bFGF可作为诊断SACC的客观参考指标。
目的：探究涎腺腺樣囊性癌（SACC）患者血清基質金屬蛋白酶9（MMP-9）的錶達與意義。方法分析2012年1月至2014年12月收治併診斷為SACC病人的臨床資料。涎腺細胞受到癌細胞侵襲的病例作為觀察組，患有SACC癌徬腺組織正常的病人納為對照組。觀察兩組血清MMP-9、基質金屬酶抑製因子（ TIMP-1）、堿性成纖維細胞生長因子（ bFGF）水平，及觀察組在不同病理參數下上述指標的水平和三項指標間的相關性。結果觀察組患者血清中MMP-9、TIMP、bFGF水平明顯高于對照組（ P <0.01）。患者的病理分型、淋巴轉移、TMN分期差異具有統計學意義（ P <0.01），其中三種指標水平腺管型顯著高于實性型，有淋巴轉移顯著高于無淋巴轉移，TMN分期T3~T4高于T1~T2。MMP-9與TIMP-1（ r =0.700，P <0.001）、bFGF（ r =0.799，P <0.001）呈顯著的正相關。結論 MMP-9、TIMP-1、bFGF隨著SACC患者病理分型、淋巴轉移、TMN分期的髮展具有協同增高的關繫；MMP-9與TIMP-1、bFGF呈顯著的正相關。血清中MMP-9、TIMP-1、bFGF可作為診斷SACC的客觀參攷指標。
목적：탐구연선선양낭성암（SACC）환자혈청기질금속단백매9（MMP-9）적표체여의의。방법분석2012년1월지2014년12월수치병진단위SACC병인적림상자료。연선세포수도암세포침습적병례작위관찰조，환유SACC암방선조직정상적병인납위대조조。관찰량조혈청MMP-9、기질금속매억제인자（ TIMP-1）、감성성섬유세포생장인자（ bFGF）수평，급관찰조재불동병리삼수하상술지표적수평화삼항지표간적상관성。결과관찰조환자혈청중MMP-9、TIMP、bFGF수평명현고우대조조（ P <0.01）。환자적병리분형、림파전이、TMN분기차이구유통계학의의（ P <0.01），기중삼충지표수평선관형현저고우실성형，유림파전이현저고우무림파전이，TMN분기T3~T4고우T1~T2。MMP-9여TIMP-1（ r =0.700，P <0.001）、bFGF（ r =0.799，P <0.001）정현저적정상관。결론 MMP-9、TIMP-1、bFGF수착SACC환자병리분형、림파전이、TMN분기적발전구유협동증고적관계；MMP-9여TIMP-1、bFGF정현저적정상관。혈청중MMP-9、TIMP-1、bFGF가작위진단SACC적객관삼고지표。
Objective The aim of this study is to explore the serum expression and significance of matrix metalloproteinase 9 in salivary gland adenoid cystic carcinoma. Methods Clinical data of patients with salivary gland adenoid cystic carcinoma received treatment from January 2012 to December 2014 was analyzed retrospectively. We set the cases of salivary gland adenoid cystic carcinoma which have invasion of Salivary gland as the observation group,while patients without invasion of salivary gland as the control group. The levels of serum MMP-9,TIMP-1,bF-GF were observed between the two groups,and related to different levels and pathological parameters three indicators among these indicators in ob-servation group. Results The serum level of MMP-9,TIMP,bFGFin observation group was significantly higher than in the control group( P <0. 01). The difference of pathological type,lymph node metastases,TMN stages is statistically significant( P <0. 01),and the serum level of MMP-9 and TIMP,bFGF in tubular type was significantly higher than solid type. The lymph node metastasis was significantly higher than those without lymph node metastasis. The TMN staging T3~T4 was higher than T1~T2. MMP-9 and TIMP-1( r =0. 700,P <0. 001). The bFGF ( r =0. 799,P <0. 001)of observation group show significant positive correlation. Conclusion MMP-9,TIMP-1,bFGF in patients with cystic carcinoma salivary gland pathological type,lymph node metastasis,TMN stage development have a synergistic relationship. Increased MMP-9 and TIMP -1,bFGF showed a significant positive correlation. MMP -9,TIMP -1 and bFGF in serum can be used as a objective reference index for diagnosing of salivary gland adenoid cystic cancer.
