CAJ | 학술논문

目的：本研究利用Meta分析的方法，综合评价中国人载脂蛋白E基因多态性与2型糖尿病合并冠心病的相关性。方法计算机及手工检索2014年12月以前中外有关中国汉族人群载脂蛋白E基因多态性与2型糖尿病合并冠心病关系的病例-对照研究。在评价纳入研究质量、提取有效数据后，采用RevMan 5.0软件进行Meta分析。结果共纳入5个病例对照研究，包括2型糖尿病并冠心病组646例，2型糖尿病无冠心病组752例。Meta分析结果显示：文献无明显发表偏倚。携带载脂蛋白Eε3/3基因型的人群2型糖尿病并冠心病的发病风险降低（ OR=0.51，95%CI：0.37~0.71），ε3/4基因型发病风险增高（OR=2.20，95%CI：1.52~3.20）；ε4等位基因发病风险增高（OR=2.07，95%CI：1.49~2.87）。结论中国汉族人群载脂蛋白Eε3/3基因型、ε3/4基因型、ε4等位基因多态性可能与2型糖尿病合并冠心病的发病有关。
목적：본연구이용Meta분석적방법，종합평개중국인재지단백E기인다태성여2형당뇨병합병관심병적상관성。방법계산궤급수공검색2014년12월이전중외유관중국한족인군재지단백E기인다태성여2형당뇨병합병관심병관계적병례-대조연구。재평개납입연구질량、제취유효수거후，채용RevMan 5.0연건진행Meta분석。결과공납입5개병례대조연구，포괄2형당뇨병병관심병조646례，2형당뇨병무관심병조752례。Meta분석결과현시：문헌무명현발표편의。휴대재지단백Eε3/3기인형적인군2형당뇨병병관심병적발병풍험강저（ OR=0.51，95%CI：0.37~0.71），ε3/4기인형발병풍험증고（OR=2.20，95%CI：1.52~3.20）；ε4등위기인발병풍험증고（OR=2.07，95%CI：1.49~2.87）。결론중국한족인군재지단백Eε3/3기인형、ε3/4기인형、ε4등위기인다태성가능여2형당뇨병합병관심병적발병유관。
Objective To investigate the association of polymorphism of apolipoprotein E( APO E)gene and type 2 diabetic patients with coronary heart disease among the Chinese Han population. Methods Case-control studies on polymorphism of apolipoprotein E gene and type 2 diabetic patients with coronary heart disease among the Chinese Han population were collected. The quality of the included studies was evaluated and the data was extracted. RevMan 5. 0 software was used for meta-analysis. Results A total of five studies were identified,involving 646 ca-ses in the type 2 diabetic patients with coronary heart disease group and 752 cases in the control group. The results of meta-analysis showed that type 2 diabetic patients withε3/3 genotypes had lower risks to coronary heart disease(OR=0. 51,95% CI:0. 37 to 0. 71),ε3/4 genotypes had higher risks to coronary heart disease(OR=2. 20,95%CI:1. 52 to 3. 20)andε4 allele had higher risks to coronary heart disease(OR=2. 07, 95% CI:1. 49 to 2. 87). Conclusion Current evidence suggests that there is association between the polymorphism of apolipoprotein E gene and the risk to type 2 diabetic patients with coronary heart disease among the Chinese Han population.