中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2015年
6期
435-439
,共5页
李红琏%尹雪%贾俊栋%岳卫东
李紅璉%尹雪%賈俊棟%嶽衛東
리홍련%윤설%가준동%악위동
老年人%皮质下缺血性血管病%认知功能%脑白质病变%腔隙性脑梗死
老年人%皮質下缺血性血管病%認知功能%腦白質病變%腔隙性腦梗死
노년인%피질하결혈성혈관병%인지공능%뇌백질병변%강극성뇌경사
aged%subcortical ischemic vascular disease%cognitive function%white matter lesions%lacunar infarction
目的:研究皮质下缺血性血管病影像学特点与老年人认知功能的相关性。方法收集2014年9月至2015年1月哈尔滨医科大学附属第二医院神经内科住院部99例皮质下缺血性血管病患者的临床资料,分析头部磁共振成像(MRI)的检查结果,根据基底节和丘脑区腔隙性脑梗死(LI)数目及脑白质病变(WML)患者的胆碱能通路高信号评分量表(CHIPS)的评分进行分组;采用蒙特利尔认知功能评估量表(MoCA,北京版)和阿尔茨海默病评定量表认知分量表(ADAS-Cog)作为认知评估工具,分析WML和LI病变程度与认知功能障碍是否存在相关性。结果根据MoCA和ADAS-Cog评分,LI和WML的中度组与轻度组比较认知功能均没有受到影响(P>0.05);重度组与轻度组比较,认知功能障碍均显著受到影响(P<0.05)。基底节和丘脑区多发性LI数目<7时,轻、中度WML组与对照组相比,认知功能没有受到影响(P>0.05);基底节和丘脑区多发性LI数目≥7时,轻中度WML组与对照组相比认知功能显著受到影响(P<0.05)。结论严重WML或基底节和丘脑区多发性LI可引起认知功能下降;轻、中度WML同时伴有基底节和丘脑区多发性LI的老年人认知功能也会下降。
目的:研究皮質下缺血性血管病影像學特點與老年人認知功能的相關性。方法收集2014年9月至2015年1月哈爾濱醫科大學附屬第二醫院神經內科住院部99例皮質下缺血性血管病患者的臨床資料,分析頭部磁共振成像(MRI)的檢查結果,根據基底節和丘腦區腔隙性腦梗死(LI)數目及腦白質病變(WML)患者的膽堿能通路高信號評分量錶(CHIPS)的評分進行分組;採用矇特利爾認知功能評估量錶(MoCA,北京版)和阿爾茨海默病評定量錶認知分量錶(ADAS-Cog)作為認知評估工具,分析WML和LI病變程度與認知功能障礙是否存在相關性。結果根據MoCA和ADAS-Cog評分,LI和WML的中度組與輕度組比較認知功能均沒有受到影響(P>0.05);重度組與輕度組比較,認知功能障礙均顯著受到影響(P<0.05)。基底節和丘腦區多髮性LI數目<7時,輕、中度WML組與對照組相比,認知功能沒有受到影響(P>0.05);基底節和丘腦區多髮性LI數目≥7時,輕中度WML組與對照組相比認知功能顯著受到影響(P<0.05)。結論嚴重WML或基底節和丘腦區多髮性LI可引起認知功能下降;輕、中度WML同時伴有基底節和丘腦區多髮性LI的老年人認知功能也會下降。
목적:연구피질하결혈성혈관병영상학특점여노년인인지공능적상관성。방법수집2014년9월지2015년1월합이빈의과대학부속제이의원신경내과주원부99례피질하결혈성혈관병환자적림상자료,분석두부자공진성상(MRI)적검사결과,근거기저절화구뇌구강극성뇌경사(LI)수목급뇌백질병변(WML)환자적담감능통로고신호평분량표(CHIPS)적평분진행분조;채용몽특리이인지공능평고량표(MoCA,북경판)화아이자해묵병평정량표인지분량표(ADAS-Cog)작위인지평고공구,분석WML화LI병변정도여인지공능장애시부존재상관성。결과근거MoCA화ADAS-Cog평분,LI화WML적중도조여경도조비교인지공능균몰유수도영향(P>0.05);중도조여경도조비교,인지공능장애균현저수도영향(P<0.05)。기저절화구뇌구다발성LI수목<7시,경、중도WML조여대조조상비,인지공능몰유수도영향(P>0.05);기저절화구뇌구다발성LI수목≥7시,경중도WML조여대조조상비인지공능현저수도영향(P<0.05)。결론엄중WML혹기저절화구뇌구다발성LI가인기인지공능하강;경、중도WML동시반유기저절화구뇌구다발성LI적노년인인지공능야회하강。
ObjectiveTo investigate theimagingfeatures ofsubcortical ischemic vascular disease(SIVD)and their correlation withcognitive impairment in the elderly.MethodsClinical data of99elderly patients(60 to 75 years old)withSIVDadmittedin ourdepartmentfrom September 2014 to January 2015 were collected.According tothe results ofheadmagnetic resonance imaging (MRI),the patients were divided based onthenumber oflacunar infarction (LI) lesionsin the basal ganglia andthalamus area,and on the severity of whitematterlesion (WML) byCholinergicPathwayHighSignalRatingScale (CHIPS). MontrealCognitive Assessment (MoCA, Beijing version) andAlzheimer’sDiseasesAssessmentScale-Cognitive(ADAS-Cog) were used as assessing tools to analyzethecorrelationof severityofLI or WMLwith cognitive function.ResultsMoCAand ADAS-Cog scale indicated that there was nodifference in cognitive functionbetween themoderate andmild LI or WML patients(P>0.05), but significant difference was seen between the severe and mild patients (P<0.05). For the patients with mild and moderate WML and severe LI (infarct lesions<7), no cognitive impairment was observed (P>0.05). While the number of infarct lesions≥7, the mild and moderate WML patientssuffered from cognitive impairment (P<0.05).Conclusion Cognitive impairment is found in the elderly patients with severe WML orwith multiple LI in the basal ganglia andthalamus area, and in those with mild and moderate WMLand coexisting multiple LI.