CAJ | 학술논문

目的：对血培养病原菌的种类分布和耐药情况进行回顾性分析，为临床用药提供依据。方法采用VersaTREK全自动血培养仪及配套血培养瓶连续监测培养细菌，阳性瓶及时转种。用MicroScan A/S-4微生物分析仪及配套试剂对分离菌进行鉴定和药敏试验。结果2460例血培养标本中共分离出237株病原菌，居前5位的病原菌依次为凝固酶阴性葡萄球菌、大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌和肠球菌。临床分布以ICU、普外科及呼吸内科为主。药敏结果显示：革兰阴性杆菌对亚胺培南高度敏感，未发现耐万古霉素和利奈唑胺的革兰阳性球菌。结论及时了解血培养结果可以为临床抗菌治疗提供依据，对提高治愈率有重要的意义。
목적：대혈배양병원균적충류분포화내약정황진행회고성분석，위림상용약제공의거。방법채용VersaTREK전자동혈배양의급배투혈배양병련속감측배양세균，양성병급시전충。용MicroScan A/S-4미생물분석의급배투시제대분리균진행감정화약민시험。결과2460례혈배양표본중공분리출237주병원균，거전5위적병원균의차위응고매음성포도구균、대장애희균、폐염극뢰백균、금황색포도구균화장구균。림상분포이ICU、보외과급호흡내과위주。약민결과현시：혁란음성간균대아알배남고도민감，미발현내만고매소화리내서알적혁란양성구균。결론급시료해혈배양결과가이위림상항균치료제공의거，대제고치유솔유중요적의의。
Objective To investigate the strains distribution and resistance characteristics of pathogenic bacteria isolated from blood culture and provide basis for clinical medication. Methods Blood samples were cultivated and continuously monitored by VersaTREK automated blood culture system with the matching blood culture bottles,and the positive bottles were transferred timely. The identification of bacteria and susceptibility test were performed by MicroScan A/S-4 bacterial automatic analyzer. Results A total of 237 strains of pathogenic bacteria were isolated from 2460 blood culture samples. The top five strains included CNS, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Enterococcus. Positive pathogens were mainly distributed in ICU, general surgical department and respiratory medicine department. Susceptibility tests showed that Gram negative bacilli were highly sensitive to imipenem and Gram positive cocci had no resistance to vancomycin and linezolid. Conclusion It is important to comprehend the blood culture results promptly for the selection of antimicrobial agents and has great significance to improve cure rate.