CAJ | 학술논문

本文研究了芬苯达唑( Fenbendazole,FBZ)在石墨烯( RGO)与离子液体( N-丁基吡啶六氟磷酸盐)复合修饰碳糊电极上的电催化氧化及电化学动力学性质。同时用CC法(计时库仑法)、计时电流法( CA)测定FBZ在RGO-[ Bupy] PF6/CPE上的电极反应动力学参数,并用方波伏安法( SWV)测定FBZ氧化峰电流( Ip )与其浓度c在4．0×10-8~1．0×10-5mol·L-1范围内呈良好线性关系,线性回归方程为Ip(μA)=1．471+5220．78c (10-3mol·L-1),R=0．9995,检测限(S/N=3)为1．4×10-9mol·L-1,在此基础上用SWV法对FBZ片剂中FBZ含量进行了电化学定量测定,RSD在0．2%~0．9%之间,回收率在99．0%~101．4%之间。
본문연구료분분체서( Fenbendazole,FBZ)재석묵희( RGO)여리자액체( N-정기필정륙불린산염)복합수식탄호전겁상적전최화양화급전화학동역학성질。동시용CC법(계시고륜법)、계시전류법( CA)측정FBZ재RGO-[ Bupy] PF6/CPE상적전겁반응동역학삼수,병용방파복안법( SWV)측정FBZ양화봉전류( Ip )여기농도c재4．0×10-8~1．0×10-5mol·L-1범위내정량호선성관계,선성회귀방정위Ip(μA)=1．471+5220．78c (10-3mol·L-1),R=0．9995,검측한(S/N=3)위1．4×10-9mol·L-1,재차기출상용SWV법대FBZ편제중FBZ함량진행료전화학정량측정,RSD재0．2%~0．9%지간,회수솔재99．0%~101．4%지간。
Objective:Electrocatalytic oxidation and its electrochemical kinetics of fenbendazole( FBZ) were investigated by Cyclic voltammetry(CV)method at carbon paste electrode(CPE)which modified by graphene(RGO)and [Bupy]PF6. The experiment re-sults indicated that FBZ electrochemical behaviors exhibits an irreversible electrochemical oxidation progress at RGO-[ Bupy] PF6/CPE,The electrochemical kinetic parameters were determined by chronocoulometry ( CC) and chronoamperometry ( CA) at RGO-[ Bupy] PF6/CPE. The oxidation peak current of FBZ versus its concentration had a good linear relationship in the concentration range of 4. 0 × 10-8 ~1. 0 × 10-5 mol·L-1and the detection limit(S/N=3)was 1. 4 × 10-9mol·L-1 by square wave voltammetric (SWV)method. The equation of linear regression was Ip(μA)=1. 471+5220. 78c(10-3mol·L-1),R=0. 9995,Also the proposed method have been applied in electrochemical quantitative determination of FBZ content in commercial tablet samples,with their rel-ative standard deviations of 0. 2% ~0. 9%and recoveries of 99. 0% ~101. 4%.