CAJ | 학술논문

miRNA（ microRNA）是一类非编码的微小RNA，其成熟体通过与靶mRNA 3ˊ端非编码区特异性结合，可在翻译和转录后水平调控靶基因的表达。有研究表明miRNA与细胞的发展、分化、凋亡和增殖有着密切的关系。miR-21（microRNA-21）作为miRNA的一个重要分子，在肿瘤的形成和耐药中发挥着重要作用。在众多耐药肿瘤细胞中，miR-21通过下调靶基因PTEN从而抑制肿瘤细胞的凋亡，增加肿瘤细胞的生长、转移和侵袭。本文就miR-21通过作于其靶基因PTEN与肿瘤耐药的关系作一综述。
miRNA（ microRNA）시일류비편마적미소RNA，기성숙체통과여파mRNA 3ˊ단비편마구특이성결합，가재번역화전록후수평조공파기인적표체。유연구표명miRNA여세포적발전、분화、조망화증식유착밀절적관계。miR-21（microRNA-21）작위miRNA적일개중요분자，재종류적형성화내약중발휘착중요작용。재음다내약종류세포중，miR-21통과하조파기인PTEN종이억제종류세포적조망，증가종류세포적생장、전이화침습。본문취miR-21통과작우기파기인PTEN여종류내약적관계작일종술。
miRNA( microRNA)are a class of small non-coding RNA,itˊs mature individuals through sPecific bind-ing target mRNA 3ˊUTR,which can modulate target genes exPression at translation and transcriPtion levels. Previous studies showed that miRNA is closely related with the cellsˊdeveloPment,differentiation,aPoPtosis and Proliferation. MiR-21(microRNA-21)as a key miRNA molecule,which Plays an imPortant role in tumor formation and drug re-sistance. In numerous drug-resistant tumor cells,miR-21 through down-regulating target gene PTEN to inhibit tumor cell aPoPtosis,accelerate the growth of tumor cells,metastasis and invasion. This article is a review about the re-lationshiP between miR-21 through regulating its target gene PTEN and tumor resistance.