CAJ | 학술논문

目的：分析手术联合5-氨基酮戊酸光动力疗法（ ALA-PDT）治疗皮肤基底细胞癌的临床疗效。方法：皮肤基底细胞癌患者30例，按抛硬币法分为观察组和对照组，每组15例。观察组患者于术前开始进行ALA-PDT治疗，每周1次，共3-7次，然后进行手术治疗，对照组患者只采取手术切除，随访16-25个月。比较两组治疗一期愈合率、有效率，并评价疗效。结果：观察组患者总有效率为100%（15/15），对照组总有效率为86.7%（13/15），差异无统计学意义（P＞0.05）。两组治疗一期愈合率、不良反应率差异具有统计学意义（P＜0.05），观察组优于对照组。结论：手术联合ALA-PDT治疗皮肤基底细胞癌具有有效、安全等优点。
목적：분석수술연합5-안기동무산광동력요법（ ALA-PDT）치료피부기저세포암적림상료효。방법：피부기저세포암환자30례，안포경폐법분위관찰조화대조조，매조15례。관찰조환자우술전개시진행ALA-PDT치료，매주1차，공3-7차，연후진행수술치료，대조조환자지채취수술절제，수방16-25개월。비교량조치료일기유합솔、유효솔，병평개료효。결과：관찰조환자총유효솔위100%（15/15），대조조총유효솔위86.7%（13/15），차이무통계학의의（P＞0.05）。량조치료일기유합솔、불량반응솔차이구유통계학의의（P＜0.05），관찰조우우대조조。결론：수술연합ALA-PDT치료피부기저세포암구유유효、안전등우점。
Objective:To analyse the clinical efficacy of surgery combined with 5-aminolevulinic acid-Photody-namic theraPy( ALA-PDT)treatment on basal cell carcinoma. Methods:Thirty basal cells cancer Patients were di-vided into observation grouP and control grouP,15 cases in each grouP. In observed grouP Patients before surgery were treated by ALA-PDT treatment once a week,a total of 3-7 times,then surgical treatment and control grouP Patients only take surgery,follow-uP for 16 to 25 months. Results:The total effective rate of the observation grouP was 100%(15/15),in the control grouP,the total effective rate was 86. 7%(13/15)(P>0. 05). Healing rates,adverse reac-tion rates were statistically significant different(P<0. 05),the observation grouP was better than the control grouP. Conclusion:Surgery combined with ALA-PDT treatment for basal cell carcinoma is effective and safe.