CAJ | 학술논문

目的：探讨luteolin对血管的抑制机制。方法：采用不同浓度luteolin处理人微血管内皮细胞，观察luteolin对内皮细胞生长，乳腺癌细胞MDA-MB 231培养液介导的内皮细胞趋化抑制作用。并探讨luteolin对内皮细胞中IL-8信号激活的抑制作用，及luteolin对血管生成抑制作用机制。结果：Luteolin对人微血管内皮细胞细胞增殖抑制作用明显（ P＜0.01）。Luteolin可抑制乳腺癌细胞MDA-MB 231培养液介导的内皮细胞趋化作用（ P＜0.01），并明显抑制IL-8对内皮细胞ERK及AKT的激活。结论：Luteolin可抑制人微血管内皮细胞增殖及乳腺癌细胞MDA-MB 231培养液介导的趋化作用，并可抑制IL-8对人微血管内皮细胞的信号激活作用，luteolin抗血管生成作用在预防恶性肿瘤复发及转移中可能有重要的作用。
목적：탐토luteolin대혈관적억제궤제。방법：채용불동농도luteolin처리인미혈관내피세포，관찰luteolin대내피세포생장，유선암세포MDA-MB 231배양액개도적내피세포추화억제작용。병탐토luteolin대내피세포중IL-8신호격활적억제작용，급luteolin대혈관생성억제작용궤제。결과：Luteolin대인미혈관내피세포세포증식억제작용명현（ P＜0.01）。Luteolin가억제유선암세포MDA-MB 231배양액개도적내피세포추화작용（ P＜0.01），병명현억제IL-8대내피세포ERK급AKT적격활。결론：Luteolin가억제인미혈관내피세포증식급유선암세포MDA-MB 231배양액개도적추화작용，병가억제IL-8대인미혈관내피세포적신호격활작용，luteolin항혈관생성작용재예방악성종류복발급전이중가능유중요적작용。
Objective:To study the blood vessels inhibition mechanism with luteolin. Methods:Different concen-trations of luteolin Processing human microvascular endothelial cells,cell growth,and MDA-MB 231 culture medium mediated chemotaxis were observed,and IL-8 signal in endothelial cell activation was observed. Results:Luteolin in-hibited microvascular endothelial cell Proliferation,and breast cancer cells MDA-MB 231 culture medium mediated of endothelial cell chemotaxis,and significantly inhibited IL-8 on endothelial cell activation. Conclusion:Luteolin can inhibit microvascular endothelial cell Proliferation and MDA -MB 231 culture medium mediated chemotaxis. Luteolin can inhibit the IL-8 signal activation of human microvascular endothelial cells,indicates luteolin anti-an-giogenesis effect in the Prevention of cancer recurrence and metastasis.