中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2015年
6期
711-714
,共4页
鹿小燕%高永红%李耿%冯润
鹿小燕%高永紅%李耿%馮潤
록소연%고영홍%리경%풍윤
代谢综合征%冠心病%痰瘀%单核细胞趋化蛋白 1%胰岛素抵抗
代謝綜閤徵%冠心病%痰瘀%單覈細胞趨化蛋白 1%胰島素牴抗
대사종합정%관심병%담어%단핵세포추화단백 1%이도소저항
metabolic syndrome%coronary heart disease%phlegm and blood stasis type%monocyte chemoattractant protein 1%insulin resistance
目的：探讨痰瘀型代谢综合征(MS)及合并冠心病(CHD)患者血清单核细胞趋化蛋白1(MCP 1)和胰岛素抵抗(IR)的关系。方法用酶联免疫吸附法测定痰瘀型单纯 MS组(16例)、MS合并 CHD组(17例)、健康对照组(14例)MCP 1和空腹血清胰岛素水平,并收集 MS的其他有关数据如腰围、空腹血糖、血脂等,计算胰岛素抵抗指数(HOMA IR)。结果单纯 MS组、MS合并 CHD组 MCP 1分别为(77.83±17.64)ng/mL和(89.15±22.92)ng/mL,与健康对照组(58.71 ng/mL±16.15 ng/mL)比较差异有统计学意义(P<0.01)。单纯MS组、MS合并CHD组HOMA IR分别为1.75±0.98、1.60±0.89,与健康对照组(1.02±0.15)比较差异均有统计学意义(P<0.05)。Pearson相关性分析：MCP 1与腰围、高血压呈正相关；HOMA IR与MCP 1、糖尿病、高血压、hs CRP均呈正相关。以 MCP 1为因变量的多元逐步线性回归分析提示：MCP 1与腰围、HOMA IR具有相关性。结论痰瘀型 MS患者 MCP 1水平增加,MS合并 CHD患者增加更明显,并与HOMA IR相关,提示MS和CHD均存在IR,MCP 1所引起的IR可能加重了 AS的进展,在 MS发展为 CHD中起到了一定作用。
目的：探討痰瘀型代謝綜閤徵(MS)及閤併冠心病(CHD)患者血清單覈細胞趨化蛋白1(MCP 1)和胰島素牴抗(IR)的關繫。方法用酶聯免疫吸附法測定痰瘀型單純 MS組(16例)、MS閤併 CHD組(17例)、健康對照組(14例)MCP 1和空腹血清胰島素水平,併收集 MS的其他有關數據如腰圍、空腹血糖、血脂等,計算胰島素牴抗指數(HOMA IR)。結果單純 MS組、MS閤併 CHD組 MCP 1分彆為(77.83±17.64)ng/mL和(89.15±22.92)ng/mL,與健康對照組(58.71 ng/mL±16.15 ng/mL)比較差異有統計學意義(P<0.01)。單純MS組、MS閤併CHD組HOMA IR分彆為1.75±0.98、1.60±0.89,與健康對照組(1.02±0.15)比較差異均有統計學意義(P<0.05)。Pearson相關性分析：MCP 1與腰圍、高血壓呈正相關；HOMA IR與MCP 1、糖尿病、高血壓、hs CRP均呈正相關。以 MCP 1為因變量的多元逐步線性迴歸分析提示：MCP 1與腰圍、HOMA IR具有相關性。結論痰瘀型 MS患者 MCP 1水平增加,MS閤併 CHD患者增加更明顯,併與HOMA IR相關,提示MS和CHD均存在IR,MCP 1所引起的IR可能加重瞭 AS的進展,在 MS髮展為 CHD中起到瞭一定作用。
목적：탐토담어형대사종합정(MS)급합병관심병(CHD)환자혈청단핵세포추화단백1(MCP 1)화이도소저항(IR)적관계。방법용매련면역흡부법측정담어형단순 MS조(16례)、MS합병 CHD조(17례)、건강대조조(14례)MCP 1화공복혈청이도소수평,병수집 MS적기타유관수거여요위、공복혈당、혈지등,계산이도소저항지수(HOMA IR)。결과단순 MS조、MS합병 CHD조 MCP 1분별위(77.83±17.64)ng/mL화(89.15±22.92)ng/mL,여건강대조조(58.71 ng/mL±16.15 ng/mL)비교차이유통계학의의(P<0.01)。단순MS조、MS합병CHD조HOMA IR분별위1.75±0.98、1.60±0.89,여건강대조조(1.02±0.15)비교차이균유통계학의의(P<0.05)。Pearson상관성분석：MCP 1여요위、고혈압정정상관；HOMA IR여MCP 1、당뇨병、고혈압、hs CRP균정정상관。이 MCP 1위인변량적다원축보선성회귀분석제시：MCP 1여요위、HOMA IR구유상관성。결론담어형 MS환자 MCP 1수평증가,MS합병 CHD환자증가경명현,병여HOMA IR상관,제시MS화CHD균존재IR,MCP 1소인기적IR가능가중료 AS적진전,재 MS발전위 CHD중기도료일정작용。
Objective To investigate the relationship between the levels of monocyte chemoattractant protein 1 (MCP 1)and insulin resistance (IR)in patients with phlegm and blood stasis type of metabolic syndrome (MS)complicated with coronary heart disease (CHD).Methods Levels of serum MCP 1 and insulin were measured by enzyme linked immunosorbent method in phlegm and blood stasis type of 16 MS patients,17 MS complicated with CHD patients and 14 healthy controls.Other information on the conven-tional clinical features of MS,such as waist circumference,fasting blood levels of glucose and fat,were col ected and homeostatic model assessment (HOMA) IR were calculated.Results There was significant difference of MCP 1 among healthy controls(58.71 ng/mL±16.15 ng/mL),subjects with MS(77.83 ng/mL±17.64 ng/mL)and subjects with MS complicated with CHD (89.15 ng/mL±22.92 ng/mL).There was significant difference of HOMA IR among healthy controls(1.02± 0.15),subjects with MS(1.75± 0.98)and sub-jects with MS complicated with CHD (1.60± 0.89).Pearson correlation analysis results suggested that MCP 1 and waist circumfer-ence,hypertension were positively correlated.HOMA IR and MCP 1,diabetes,hypertension,high sensitivity C reactive protein (hs CRP)were positively correlated.Logistic regression analysis indicated that there was statistical y significant relationship be-tween MCP 1 and waist circumference,HOMA IR.Conclusion The levels of MCP 1 was highest in patients with phlegm and blood stasis type of MS complicated with CHD and increased in patiens with MS,which were significantly correlated with HOMA IR. This indicated that IR existed both in MS and CHD,IR caused by MCP 1 might promote the progress of AS which contributing to de-velopment of CHD from MS.
