中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
17期
6-7,8
,共3页
中晚期肝癌%热疗%介入化疗栓塞术
中晚期肝癌%熱療%介入化療栓塞術
중만기간암%열료%개입화료전새술
Advanced hepatocellular carcinoma%Hyperthermia%Interventional chemotherapy embolization
目的：研究热疗与介入化疗栓塞术联合治疗中晚期肝癌的临床效果。方法：选取笔者所在医院2008年6月-2012年2月收治的80例原发性中晚期肝癌患者作为研究对象，按照随机数字表法将其分为治疗组和对照组，每组40例。治疗组采用热疗联合介入化疗栓塞术进行治疗，对照组单纯采用常规介入化疗栓塞术进行治疗。化疗方案采用四药联用。观察比较两组患者的临床疗效、卡氏评分改善情况、疼痛缓解情况和随访期间生存率的差异。结果：经治疗后，治疗组的治疗总有效率75.0%(30/40)明显高于对照组的40.0%(16/40)，卡氏评分总改善率80.0%(32/40)明显高于对照组的50.0%(20/40)，疼痛缓解率85.0%(34/40)明显高于对照组的35.0%(14/40)，差异均有统计学意义(P<0.05)。两组0.5、1、1.5年的生存率比较差异均无统计学意义(P>0.05)，而治疗组的2年生存率60.0%明显高于对照组的25.0%，差异有统计学意义(字2=10.0256，P=0.0015)。结论：热疗联合介入化疗栓塞术治疗中晚期肝癌疗效优于单纯介入化疗栓塞术，是治疗中晚期肝癌有效的综合治疗方法，值得临床推广应用。
目的：研究熱療與介入化療栓塞術聯閤治療中晚期肝癌的臨床效果。方法：選取筆者所在醫院2008年6月-2012年2月收治的80例原髮性中晚期肝癌患者作為研究對象，按照隨機數字錶法將其分為治療組和對照組，每組40例。治療組採用熱療聯閤介入化療栓塞術進行治療，對照組單純採用常規介入化療栓塞術進行治療。化療方案採用四藥聯用。觀察比較兩組患者的臨床療效、卡氏評分改善情況、疼痛緩解情況和隨訪期間生存率的差異。結果：經治療後，治療組的治療總有效率75.0%(30/40)明顯高于對照組的40.0%(16/40)，卡氏評分總改善率80.0%(32/40)明顯高于對照組的50.0%(20/40)，疼痛緩解率85.0%(34/40)明顯高于對照組的35.0%(14/40)，差異均有統計學意義(P<0.05)。兩組0.5、1、1.5年的生存率比較差異均無統計學意義(P>0.05)，而治療組的2年生存率60.0%明顯高于對照組的25.0%，差異有統計學意義(字2=10.0256，P=0.0015)。結論：熱療聯閤介入化療栓塞術治療中晚期肝癌療效優于單純介入化療栓塞術，是治療中晚期肝癌有效的綜閤治療方法，值得臨床推廣應用。
목적：연구열료여개입화료전새술연합치료중만기간암적림상효과。방법：선취필자소재의원2008년6월-2012년2월수치적80례원발성중만기간암환자작위연구대상，안조수궤수자표법장기분위치료조화대조조，매조40례。치료조채용열료연합개입화료전새술진행치료，대조조단순채용상규개입화료전새술진행치료。화료방안채용사약련용。관찰비교량조환자적림상료효、잡씨평분개선정황、동통완해정황화수방기간생존솔적차이。결과：경치료후，치료조적치료총유효솔75.0%(30/40)명현고우대조조적40.0%(16/40)，잡씨평분총개선솔80.0%(32/40)명현고우대조조적50.0%(20/40)，동통완해솔85.0%(34/40)명현고우대조조적35.0%(14/40)，차이균유통계학의의(P<0.05)。량조0.5、1、1.5년적생존솔비교차이균무통계학의의(P>0.05)，이치료조적2년생존솔60.0%명현고우대조조적25.0%，차이유통계학의의(자2=10.0256，P=0.0015)。결론：열료연합개입화료전새술치료중만기간암료효우우단순개입화료전새술，시치료중만기간암유효적종합치료방법，치득림상추엄응용。
Objective:To study the clinical effect of hyperthermia combined with interventional chemotherapy embolization in the treatment of advanced hepatocellular carcinoma.Method:80 patients with primary advanced hepatocellular carcinoma admitted to our hospital from June 2008 to February 2012 were selected as research objects,they were divided into the treatment group and the control group according to the random number table method,40 cases in each group.The treatment group was given hyperthermia combined with interventional chemotherapy embolization.The control group only received routine interventional chemotherapy embolization,the four drugs combined with chemotherapy.The clinical efficacy,KPS improvement,pain relief and survival rate during follow-up of the two groups were observed and compared.Result:After treatment,the total effective rate of the treatment group was 75.0%(30/40),which was significantly higher than 40.0%(16/40) of the control group,the total improvement rate of KPS in the treatment group was 80.0%(32/40),which was significantly higher than 50.0%(20/40) in the control group,the pain relief rate of the treatment group was 85.0%(34/40),which was significantly higher than 35.0%(14/40) of the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the survival rate of 0.5 year,l year,1.5 years between the two groups(P>0.05),the survival rate of 2 years in the treatment group was 60.0%,which was significantly higher than 25.0%in the control group, the difference was statistically significant(χ2=10.0256,P=0.0015).Conclusion:The clinical efficacy of hyperthermia combined with interventional chemotherapy embolization in the treatment of advanced hepatocellular carcinoma is better than single interventional chemoembolization,it is an effective comprehensive treatment for the treatment of advanced hepatocellular carcinoma,is worthy of clinical application.
