中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
17期
1-3,4
,共4页
冠状动脉疾病%辛伐他汀%美托洛尔%血浆同型半胱氨酸%血脂
冠狀動脈疾病%辛伐他汀%美託洛爾%血漿同型半胱氨痠%血脂
관상동맥질병%신벌타정%미탁락이%혈장동형반광안산%혈지
Coronary heart disease%Simvastatin%Metoprolol%Homocysteine%Blood lipid
目的：探讨美托洛尔与辛伐他汀对冠心病患者(CHD)心率变异性(HRV)及其血脂、血浆同型半胱氨酸(Hcy)的不同影响。方法：选取2009年8月-2012年6月于笔者所在医院经冠状动脉造影术确诊的80例CHD患者作为研究对象，按入组顺序随机将其分为辛伐他汀组和美托洛尔组，每组40例。两组患者除给予常规相同的治疗药物外，辛伐他汀组给予辛伐他汀治疗，美托洛尔组给予美托洛尔治疗，治疗持续8周。观察比较两组患者治疗前后血压、24 h动态心电图、血脂和血浆同型半胱氨酸的变化。结果：两组患者治疗后的血压、心率均有明显下降，HRV时域指标SDNN、HRVTI和频域指标TP、LF、HF、LF/HF及血脂和Hcy水平均呈现不同程度的改善(P<0.05)，而美托洛尔对HRV频域指标和Hcy水平的影响更为显著(P<0.05)。结论：美托洛尔和辛伐他汀均可改善CHD患者的血压、心率、HRV和Hcy水平，但美托洛尔在改善HRV频域指标和Hcy水平上有着更良好的作用。
目的：探討美託洛爾與辛伐他汀對冠心病患者(CHD)心率變異性(HRV)及其血脂、血漿同型半胱氨痠(Hcy)的不同影響。方法：選取2009年8月-2012年6月于筆者所在醫院經冠狀動脈造影術確診的80例CHD患者作為研究對象，按入組順序隨機將其分為辛伐他汀組和美託洛爾組，每組40例。兩組患者除給予常規相同的治療藥物外，辛伐他汀組給予辛伐他汀治療，美託洛爾組給予美託洛爾治療，治療持續8週。觀察比較兩組患者治療前後血壓、24 h動態心電圖、血脂和血漿同型半胱氨痠的變化。結果：兩組患者治療後的血壓、心率均有明顯下降，HRV時域指標SDNN、HRVTI和頻域指標TP、LF、HF、LF/HF及血脂和Hcy水平均呈現不同程度的改善(P<0.05)，而美託洛爾對HRV頻域指標和Hcy水平的影響更為顯著(P<0.05)。結論：美託洛爾和辛伐他汀均可改善CHD患者的血壓、心率、HRV和Hcy水平，但美託洛爾在改善HRV頻域指標和Hcy水平上有著更良好的作用。
목적：탐토미탁락이여신벌타정대관심병환자(CHD)심솔변이성(HRV)급기혈지、혈장동형반광안산(Hcy)적불동영향。방법：선취2009년8월-2012년6월우필자소재의원경관상동맥조영술학진적80례CHD환자작위연구대상，안입조순서수궤장기분위신벌타정조화미탁락이조，매조40례。량조환자제급여상규상동적치료약물외，신벌타정조급여신벌타정치료，미탁락이조급여미탁락이치료，치료지속8주。관찰비교량조환자치료전후혈압、24 h동태심전도、혈지화혈장동형반광안산적변화。결과：량조환자치료후적혈압、심솔균유명현하강，HRV시역지표SDNN、HRVTI화빈역지표TP、LF、HF、LF/HF급혈지화Hcy수평균정현불동정도적개선(P<0.05)，이미탁락이대HRV빈역지표화Hcy수평적영향경위현저(P<0.05)。결론：미탁락이화신벌타정균가개선CHD환자적혈압、심솔、HRV화Hcy수평，단미탁락이재개선HRV빈역지표화Hcy수평상유착경량호적작용。
Objective:To investigate the different effects of Metoprolol and Simvastatin on the heart rate variability(HRV),blood lipid and homocysteine(Hcy) of patients with coronary heart disease(CHD).Method:A total of 80 patients who were diagnosed as CHD according to the results of coronary angiography in our hospital from August 2009 to June 2012 were selected as research objects.All patients were randomly divided into the Simvastatin group and the Metoprolol group according to the group order,40 cases in each group.Patients of two groups received the same conventional drug therapy,on the basis of drug therapy,the Simvastatin group was treated with Simvastatin,the Metoprolol group was treated with Metoprolol,the treatment lasted for 8 weeks.The changes of blood pressure,24 h dynamic electrocardiogram,blood lipid and homocysteine between the two groups before and after treatment were observed and compared. Result:The blood pressures and heart rate all decreased obviously in the two groups after treatment,the indicators of SDNN,HRVTI,TP,LF,HF,LF/HF, blood liquid and Hcy were all improved when treated with Simvastatin or Metoprolol respectively(P<0.05).However,compared with the Simvastatin group,the changes of HRV frequency-domain indexes and level of Hcy in the Metoprolol group were significant(P<0.05).Conclusion:Metoprolol and Simvastatin both can improve the blood pressure,heart rate,HRV and Hcy of patients with CHD,but Metoprolol in the improvement of HRV frequency index and Hcy level has a good effect.
