CAJ | 학술논문

目的：评价临床药师干预电子计算机X射线断层扫描技术（ CT）增强扫描中对比剂用药指导的效果。方法选取CT增强扫描病例1036例患者作为试验组，同期CT增强扫描956例患者作为对照组，临床药师干预试验组CT增强扫描中的对比剂用药指导，对照组给予常规对比剂用药指导，比较2组患者对比剂不良反应发生情况。结果试验组对比剂不良反应发生率为3.38％，明显低于对照组的8.58％（ P＜0.05）。轻度反应表现为恶心、头痛、局部荨麻疹；中度反应表现为荨麻疹、胸闷、气促；重度反应主要是急诊心电图提示心肌梗死。结论临床药师参与放射科医师CT增强对比剂用药指导，为医师、患者双方提供安全、有效的对比剂用药方案，降低对比剂不良反应。
목적：평개림상약사간예전자계산궤X사선단층소묘기술（ CT）증강소묘중대비제용약지도적효과。방법선취CT증강소묘병례1036례환자작위시험조，동기CT증강소묘956례환자작위대조조，림상약사간예시험조CT증강소묘중적대비제용약지도，대조조급여상규대비제용약지도，비교2조환자대비제불량반응발생정황。결과시험조대비제불량반응발생솔위3.38％，명현저우대조조적8.58％（ P＜0.05）。경도반응표현위악심、두통、국부담마진；중도반응표현위담마진、흉민、기촉；중도반응주요시급진심전도제시심기경사。결론림상약사삼여방사과의사CT증강대비제용약지도，위의사、환자쌍방제공안전、유효적대비제용약방안，강저대비제불량반응。
Objective To explore the effect of clinical pharmacists'inter-vention on medication guidance of contrast agent in computed tomography ( CT) enhancement scanning.Methods A total of 1036 cases under-went CT enhancement scanning were selected as trial group, and 956 ca-ses of CT enhancement scan in the same period as control group.Patients in the trial group were given clinical pharmacist's intervention on CT en-hancement scanning in guiding medication of contrast agent, and those in the control group were given conventional medication guide of contrast agent.The incidences of contrast agent-related adverse reactions were compared between two groups.Results The incidence rate of adverse re-actions in trial group was 3.38%, significantly lower than 8.58%in the control group ( P <0.05 ) .The mild reactions mainly were nausea, headache, local urticaria, moderate reaction mainly were manifested as urticaria, chest tightness, shortness of breath, and severe reaction was myocardial infarction shown in emergency ECG.Conclusion The clini-cal pharmacists'participation in medication guide of CT contrast agent with radiologists has provided a safe, effective contrast agent regimen for physicians and patients, meanwhile, reduced the incidence rate of con-trast agent-related adverse reactions.