CAJ | 학술논문

目的：了解我国尿标本分离粪肠球菌和屎肠球菌耐药状况。方法针对尿标本中分离的189株粪肠球菌和224株屎肠球菌，用琼脂二倍稀释法进行药物敏感性分析。检测肠球菌万古霉素耐药基因型。结果粪肠球菌对氨苄西林和左氧氟沙星的敏感率分别为87.8％和61.4％，屎肠球菌对氨苄西林和左氧氟沙星的敏感率仅为6.3％和5.4％。屎肠球菌和粪肠球菌对米诺环素的敏感率分别为51.3％和19.6％。粪肠球菌和屎肠球菌对红霉素和利福平的敏感率均不足25％。粪肠球菌对万古霉素和替考拉宁的敏感率分别为99.5％和100.0％，屎肠球菌对万古霉素和替考拉宁的敏感率分别为96.9％和97.8％。1株万古霉素耐药粪肠球菌和7株万古霉素耐药屎肠球菌均携带 vanA 基因。结论尿分离粪肠球菌对氨苄西林和左氧氟沙星较为敏感，屎肠球菌对米诺环素较为敏感。肠球菌对万古霉素和替考拉宁尚保持较高敏感性。
목적：료해아국뇨표본분리분장구균화시장구균내약상황。방법침대뇨표본중분리적189주분장구균화224주시장구균，용경지이배희석법진행약물민감성분석。검측장구균만고매소내약기인형。결과분장구균대안변서림화좌양불사성적민감솔분별위87.8％화61.4％，시장구균대안변서림화좌양불사성적민감솔부위6.3％화5.4％。시장구균화분장구균대미낙배소적민감솔분별위51.3％화19.6％。분장구균화시장구균대홍매소화리복평적민감솔균불족25％。분장구균대만고매소화체고랍저적민감솔분별위99.5％화100.0％，시장구균대만고매소화체고랍저적민감솔분별위96.9％화97.8％。1주만고매소내약분장구균화7주만고매소내약시장구균균휴대 vanA 기인。결론뇨분리분장구균대안변서림화좌양불사성교위민감，시장구균대미낙배소교위민감。장구균대만고매소화체고랍저상보지교고민감성。
Objective To investigate resistance of the Enterococcus faecalis and Enterococcus faecium isolated from urine in China.Methods The antimicrobial susceptibility of 189 isolates of Enterococcus faecalis and 224 isolates of Enterococcus faecium from urine was determined by argar dilu-tion.The vancomycin resistance genes were analysis of vancomycin resis-tant Enterococcus.Results The susceptibility rate of Enterococcus faecalis to ampicillin and levofloxacin were 87.8%and 61.4%, respectively, and the susceptibility of Enterococcus faecium to ampicillin and levofloxacin were 6.1% and 5.4%, respectively.The susceptibility rate of Enteroco-ccus faecium and Enterococcus faecalis to minocycline were 51.3% and 19.6%, respectively.The susceptibility rate of Enterococcus faecalis and Enterococcus faecium to erythromycin and rifampin were lower than 25%.The susceptibility rate of Enterococcus faecalis to vancomycin and teicopla-nin were 99.5%and 100.0%, and the susceptibility rate of Enterococcus faecium to vancomycin and teicoplanin were 96.9% and 97.8%.vanA gene as found in 1 isolate of vancomycin resistant Enterococcus faecalis and 5 isolates of vancomycin resistant Enterococcus faecium.Conclusion En-terococcus faecalis isolated from urine were sensitive to ampicillin and levo-floxacin, and Enterococcus faecium were more susceptible to minocycline.The Enterococcus remained sensitive to vancomycin and teicoplanin.