CAJ | 학술논문

目的：研究燕麦麸β-葡聚糖的降血糖和抗氧化功效。方法将小鼠分为正常组和模型组，模型组通过注射四氧嘧啶建立糖尿病模型。比较分析各组小鼠体重、摄食量、饮水量、血糖值、耐糖量、肝脏超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)和丙二醛(MDA)含量。结果高剂量组对糖尿病小鼠摄食饮水量的减少和体重增加有显著影响且高剂量组小鼠血糖值降低25.39%。燕麦麸β-葡聚糖对正常小鼠的体重、饮水量、摄食量、血糖值、耐糖量没有明显的作用。与对照组比较，模型组小鼠血糖曲线下面积、SOD、GSH-PX的活性显著提高，体内MDA的含量显著降低。结论燕麦麸β-葡聚糖能降低糖尿病小鼠的血糖值和提高糖尿病小鼠的抗氧化能力，对正常小鼠没有影响。
목적：연구연맥부β-포취당적강혈당화항양화공효。방법장소서분위정상조화모형조，모형조통과주사사양밀정건립당뇨병모형。비교분석각조소서체중、섭식량、음수량、혈당치、내당량、간장초양화물기화매(SOD)、곡광감태과양화물매(GSH-PX)화병이철(MDA)함량。결과고제량조대당뇨병소서섭식음수량적감소화체중증가유현저영향차고제량조소서혈당치강저25.39%。연맥부β-포취당대정상소서적체중、음수량、섭식량、혈당치、내당량몰유명현적작용。여대조조비교，모형조소서혈당곡선하면적、SOD、GSH-PX적활성현저제고，체내MDA적함량현저강저。결론연맥부β-포취당능강저당뇨병소서적혈당치화제고당뇨병소서적항양화능력，대정상소서몰유영향。
Objective To study the effects of oat bran β-glucan on hyooglycemic and antioxidant. Methods The mice were divided into normal group and model group. The models of experimental diabetes were built by injecting Alloxan in mouse. The body weight, food intake, water intake, blood glucose levels, the glucose tolerance, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in the liver, and organ index of mice were analyzed. Results The high dosage group could reduce the average amount ingestion and water intake and increase the average weight of diabetic mice obviously, and the glucose levels of high dosage group were 25.39%. Oat bran β-glucan made no significant effect on normal mice’s weight, water intake, food intake, blood glucose level, and glucose tolerance. Compared with control group, model group in mice the area under blood glucose curve, SOD, and GSH-PX activity were increased significantly, and the body MDA content was decreased significantly. Conclusion The results indicate that oat bran β-glucan has no effect on normal mice but can decrease the blood glucose levels of diabetic mice and improve the antioxidant capacity of diabetic mice.