CAJ | 학술논문

目的探讨羟氯喹、氯雷他定联合氟芬那酸丁酯软膏治疗多形性日光疹的疗效和安全性.方法多形性日光疹患者48例,随机分为治疗1组和治疗2组,每组24例,用药时间共8周.两组患者均口服羟氯喹200 mg,每天2次,氯雷他定每天10 mg,4周后,均改为单独口服羟氯喹每次100 mg,每天2次,再服4周,同时辅以外用药.治疗1组患者辅以氟芬那酸丁酯软膏外搽患处,每天2次,共8周;治疗2组患者辅以糠酸莫米松乳膏外搽患处,每天2次,外用2周后,改为外用氟芬那酸丁酯软膏,每天2次,再使用6周.2周为1个疗程,共4个疗程,即8周.每个疗程结束时评价两组的有效率,治疗前后评价两组患者的皮肤病总评分和红斑评分.结果治疗1组第14、28、42、56天的总评分/红斑评分有效例数分别为0/1、3/5、12/13、19/18;治疗2组分别为1/0、4/5、12/11、20/17;两组患者各观测点有效率比较,差异无统计学意义(P＞0.05).两组患者治疗后总评分及红斑评分均有明显降低,与治疗前相比,差异有统计学意义(P＜0.05).两组均未出现严重的不良反应.结论羟氯喹、氯雷他定联合氟芬那酸丁酯软膏治疗多形性日光疹疗效好,安全性高.外用氟芬那酸丁酯软膏治疗以红斑表现为主的多形性日光疹疗效较佳.
목적 탐토간록규、록뢰타정연합불분나산정지연고치료다형성일광진적료효화안전성.방법 다형성일광진환자48례,수궤분위치료1조화치료2조,매조24례,용약시간공8주.량조환자균구복간록규200 mg,매천2차,록뢰타정매천10 mg,4주후,균개위단독구복간록규매차100 mg,매천2차,재복4주,동시보이외용약.치료1조환자보이불분나산정지연고외차환처,매천2차,공8주;치료2조환자보이강산막미송유고외차환처,매천2차,외용2주후,개위외용불분나산정지연고,매천2차,재사용6주.2주위1개료정,공4개료정,즉8주.매개료정결속시평개량조적유효솔,치료전후평개량조환자적피부병총평분화홍반평분.결과 치료1조제14、28、42、56천적총평분/홍반평분유효례수분별위0/1、3/5、12/13、19/18;치료2조분별위1/0、4/5、12/11、20/17;량조환자각관측점유효솔비교,차이무통계학의의(P＞0.05).량조환자치료후총평분급홍반평분균유명현강저,여치료전상비,차이유통계학의의(P＜0.05).량조균미출현엄중적불량반응.결론 간록규、록뢰타정연합불분나산정지연고치료다형성일광진료효호,안전성고.외용불분나산정지연고치료이홍반표현위주적다형성일광진료효교가.
Objective To evaluate the efficacy and safety of hydroxychloroquine combined with butyli flufenamatum ointment and other drugs for the treatment of polymorphous light eruption (PLE).Methods A total of 48 patients with PLE were randomly and equally classified into group 1 and group 2.Both groups took hydroxychloroquine 200 mg twice a day and loratadine 10 mg per day for the initial 4 weeks,then took hydroxychloroquine 100 mg twice a day alone for another 4 weeks.Group 1 also topically applied butyli flufenamatum ointment twice a day during the 8 weeks,while group 2 applied mometasone furoate cream twice a day for the first 2 weeks followed by butyli flufenamatum ointment twice a day for another 6 weeks.Each treatment cycle lasted 2 weeks,and both groups received 4 cycles of treatment.Patients were evaluated for the response rate at the end of each cycle,and for the total symptom score and erythema score before and after the 8-week treatment.Statistical analysis was carried out using t test,chi-square test,Fisher's exact test and repeated-measures analysis of variance with the SPSS17.0 software.Results On day 14,28,42 and 56,the total score improved in 0,3,12 and 19 patients in group 1 respectively,and in 1,4,12 and 20 patients in group 2 respectively;the erythema score improved in 1,5,13 and 18 patients in group 1 respectively,and in 0,5,11 and 17 patients in group 2 respectively.No significant difference was observed between the two groups in response rates at any of the above four time points (P ＞ 0.05).Both the total score and erythema score significantly decreased after the 8-week treatment in both groups compared with the pretreatment scores (both P ＜ 0.05).No serious adverse reaction was observed in either of the two groups.Conclusions Hydroxychloroquine combined with loratadine and butyli flufenamatum ointment shows high efficacy and safety for the treatment of PLE.Topical butyli flufenamatum ointment is highly effective for the treatment of PLE,especially for PLE cases mainly presenting with erythema.