CAJ | 학술논문

目的探讨肢端血管皮炎的临床病理特征及鉴别诊断.方法回顾性分析12例肢端血管皮炎患者的临床和病理资料.结果肢端血管皮炎临床表现为局限性的棕色至紫红色的斑片、斑块、结节及溃疡形成.皮损均位于下肢,双侧及单侧受累者各6例.组织病理检查:真皮上中部小叶状或团块状毛细血管和小静脉增生,管腔圆形,规则,血管内皮细胞肿胀,可见程度不等的红细胞外溢、含铁血黄素沉积、真皮纤维化及稀疏炎细胞浸润.病变累及真皮浅层者3例,真皮中上部者8例,真皮全层者1例.免疫组化检查:血管内皮细胞CD34和CD31阳性,血管周细胞CD34阴性.结论肢端血管皮炎具有特殊的临床及病理特征,病理学检查是诊断肢端血管皮炎的重要依据.
목적 탐토지단혈관피염적림상병리특정급감별진단.방법 회고성분석12례지단혈관피염환자적림상화병리자료.결과 지단혈관피염림상표현위국한성적종색지자홍색적반편、반괴、결절급궤양형성.피손균위우하지,쌍측급단측수루자각6례.조직병리검사:진피상중부소협상혹단괴상모세혈관화소정맥증생,관강원형,규칙,혈관내피세포종창,가견정도불등적홍세포외일、함철혈황소침적、진피섬유화급희소염세포침윤.병변루급진피천층자3례,진피중상부자8례,진피전층자1례.면역조화검사:혈관내피세포CD34화CD31양성,혈관주세포CD34음성.결론 지단혈관피염구유특수적림상급병리특정,병이학검사시진단지단혈관피염적중요의거.
Objective To investigate the clinicopathologic features and differential diagnosis ofacroangiodermatitis (AM).Methods Clinical and pathological data on 12 patients with AM were retrospectively reviewed.Results Clinical manifestations of AM consisted of circumscribed brown to violaeeous macules,plaques,nodules and ulceration.Lesions were located in bilateral legs in 6 patients,and in unilateral legs in the other 6 patients.Histopathological examination revealed an increased number of lobular or clump-shaped capillaries and small veins whose lumens were round and regular,swelling of vascular endothelial cells,and different degrees of erythrocyte extravasation,hemosiderin deposition,dermal fibrosis and sparse infiltrates of inflammatory cells.The lesions were histologically located in the superficial dermis in 3 cases,in the upper and middle dermis in 8 cases,and in the entire dermis in 1 case.Immunohistochemical studies showed that vascular endothelial cells stained positive for CD31 and CD34,while perivascular cells stained negative for CD34.Conclusions AM has specific clinical and pathological manifestations,and pathological examination is essential for the diagnosis of AM.