CAJ | 학술논문

目的：对比细胞DNA定量分析与巴氏染色细胞学诊断宫颈癌及癌前病变的效果。方法接受宫颈细胞学检查者共1327例[正常1299例，宫颈炎3例、宫颈上皮内瘤变（ CIN）Ⅰ3例、CINⅡ5例、CINⅢ6例、宫颈癌11例]。两种检查结果任一出现阳性即建议病患进行阴道镜病理活检，共34例行病理活检。以病理诊断为“金标准”，分别计算巴氏染色细胞学检查和细胞DNA定量分析法诊断的灵敏度、特异度、阳性预测值及阴性预测值。结果巴氏染色细胞学诊断共检出27例（2．0％）阳性病例，细胞DNA定量分析法共检出28例（2．1％）阳性病例，细胞DNA定量分析法诊断CINⅢ以上灵敏度、阴性预测值均高于巴氏染色细胞学诊断结果，但两者特异度、阳性预测值相差不大。结论细胞DNA定量分析法诊断宫颈癌及癌前病变的灵敏度较巴氏染色细胞学诊断高，且两者特异度相当。
목적：대비세포DNA정량분석여파씨염색세포학진단궁경암급암전병변적효과。방법접수궁경세포학검사자공1327례[정상1299례，궁경염3례、궁경상피내류변（ CIN）Ⅰ3례、CINⅡ5례、CINⅢ6례、궁경암11례]。량충검사결과임일출현양성즉건의병환진행음도경병리활검，공34례행병리활검。이병리진단위“금표준”，분별계산파씨염색세포학검사화세포DNA정량분석법진단적령민도、특이도、양성예측치급음성예측치。결과파씨염색세포학진단공검출27례（2．0％）양성병례，세포DNA정량분석법공검출28례（2．1％）양성병례，세포DNA정량분석법진단CINⅢ이상령민도、음성예측치균고우파씨염색세포학진단결과，단량자특이도、양성예측치상차불대。결론세포DNA정량분석법진단궁경암급암전병변적령민도교파씨염색세포학진단고，차량자특이도상당。
Objective To compare DNA quantitative analysis versus Papanicolaou staining cytological test for the diagnosis of cervical carcinoma and precancerous lesions.Methods There were 1 327 cases of cervical cytology (1 299 normal,3 cervicitis,3 cervical intraepithelial neoplasia(CIN)Ⅰ,5 CINⅡ,6 CINⅢ,11 cervical carcinoma) in the study.The pathological colposcopy was recommended to the patients when either of their results of the two tests mentioned above was positive,of which 34 received pathological biopsy.The sensitivity,specificity,positive predictive value and negative predictive value of DNA quantitative analysis/Papanicolaou staining cytological test were calculated,respectively, with the pathological diagnosis as the gold standard.Results Papanicolaou staining cytological test revealed that there were 27(2.0%) positive cases,while DNA quantitative analysis revealed that there were 28(2.1%) positive cases.The sensitivity and negative predictive value of DNA quantitative analysis applied to the diagnosis of CINⅢor the severer were higher than those of Papanicolaou staining cytological test,but the specificity and positive predictive value showed little significant difference between DNA quantitative analysis and Papanicolaou staining cytological test.Conclusion DNA quantitative analysis achieves a higher sensitivity in the diagnosis of cervical carcinoma and precancerous lesions in contrast with Papanicolaou staining cytological test,with a noninferior specificity.