CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病（ COPD）患者外周血 T 淋巴细胞的表达及与肺功能的关系。方法检测COPD缓解期患者60例（COPD缓解期组）、慢性阻塞性肺疾病急性加重期（AECOPD）患者60例（AECOPD组）和体检健康者50例（对照组）的外周血CD3＋、CD4＋、CD8＋及 CD4＋／CD8＋T淋巴细胞水平。 COPD 缓解期组在治疗前进行肺功能检查。结果 AECOPD组及COPD缓解期组血清CD3＋、CD4＋、CD4＋／CD8＋T淋巴细胞水平均低于对照组（P＜0．05），CD8＋T淋巴细胞水平高于对照组（P＜0．05）。 COPD缓解期组血清CD3＋、CD4＋、CD4＋／CD8＋T淋巴细胞水平高于 AECOPD组， CD8＋T淋巴细胞水平低于 AECOPD 组（ P ＜0．05）。 COPD 缓解期组患者 CD4＋T淋巴细胞水平与第一秒用力呼气容积（FEV1）及用力肺活量（FVC）呈显著正相关（P＜0．05），CD4＋／CD8＋T淋巴细胞水平与FEV1及FVC呈正相关（P＜0．05）， CD8＋T淋巴细胞水平与FEV1及FVC呈负相关（P＜0．05），CD3＋T淋巴细胞水平与FEV1和FVC无统计学相关性（P＞0．05）。结论 COPD患者存在细胞免疫功能障碍，且随着病情的加重和肺功能的降低其免疫功能呈进行性减退。
목적：탐토만성조새성폐질병（ COPD）환자외주혈 T 림파세포적표체급여폐공능적관계。방법검측COPD완해기환자60례（COPD완해기조）、만성조새성폐질병급성가중기（AECOPD）환자60례（AECOPD조）화체검건강자50례（대조조）적외주혈CD3＋、CD4＋、CD8＋급 CD4＋／CD8＋T림파세포수평。 COPD 완해기조재치료전진행폐공능검사。결과 AECOPD조급COPD완해기조혈청CD3＋、CD4＋、CD4＋／CD8＋T림파세포수평균저우대조조（P＜0．05），CD8＋T림파세포수평고우대조조（P＜0．05）。 COPD완해기조혈청CD3＋、CD4＋、CD4＋／CD8＋T림파세포수평고우 AECOPD조， CD8＋T림파세포수평저우 AECOPD 조（ P ＜0．05）。 COPD 완해기조환자 CD4＋T림파세포수평여제일초용력호기용적（FEV1）급용력폐활량（FVC）정현저정상관（P＜0．05），CD4＋／CD8＋T림파세포수평여FEV1급FVC정정상관（P＜0．05）， CD8＋T림파세포수평여FEV1급FVC정부상관（P＜0．05），CD3＋T림파세포수평여FEV1화FVC무통계학상관성（P＞0．05）。결론 COPD환자존재세포면역공능장애，차수착병정적가중화폐공능적강저기면역공능정진행성감퇴。
Objective To investigate the expression of peripheral blood T lymphocytes and its relationship with lung function among patients with chronic obstructive pulmonary disease(COPD).Methods The levels of CD3+,CD4+,CD8+and CD4+/CD8+T lymphocytes were detected among 60 patients with stable COPD(stable COPD group),60 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD,AECOPD group) and 60 normal controls.Lung function test was performed in the stable COPD group before treatment. Results The serum levels of CD3+,CD4+and CD4+/CD8+T lymphocytes were lower while the level of CD8+T lymphocytes was higher in the AECOPD group and stable COPD group compared with the controls(P<0.01).The serum levels of CD3+,CD4+and CD4+/CD8 +T lymphocytes were higher while the level of CD8 +T lymphocytes was lower in the stable COPD group compared with AECOPD group (P<0.05).In the stable COPD group,the level of CD4 +T lymphocytes positively correlated with forced expiratory volume in one second (FEV1) and forced vital capacity(FVC) significantly(P<0.01),the level of CD4 +/CD8 +T lymphocytes positively correlated with FEV1 and FVC(P<0.05),the level of CD8 +T lymphocytes negatively correlated with FEV1 and FVC(P<0.05),and the level of CD3 +T lymphocytes showed no correlation with FEV1 and FVC( P>0.05) .Conclusion Cellular immune dysfunction can be observed in COPD patients,which presents a progressive loss of immune function with the increasing severity of the disease and poorer lung function.