中国药事
中國藥事
중국약사
CHINESE PHARMACEUTICAL AFFAIRS
2015年
6期
623-635
,共13页
姜树银%巩丽萍%赵艳霞%石峰%郭常川
薑樹銀%鞏麗萍%趙豔霞%石峰%郭常川
강수은%공려평%조염하%석봉%곽상천
近红外分析%NIR模型%基本药物%药品快速分析
近紅外分析%NIR模型%基本藥物%藥品快速分析
근홍외분석%NIR모형%기본약물%약품쾌속분석
near-infrared%NIR model%essential drugs%drug rapid analysis
目的：建立氯氮平片等56个品种药物的近红外快速分析模型并进行验证。方法：收集不同企业生产的药物固体制剂，采集其近红外漫反射光谱，建立定性分析模型，经不同人员采用不同仪器测定相同批次的样品对建立的模型进行验证。结果：所建定性分析模型均可以明确区分不同厂家样本，且筛查快速、准确。结论：所建模型可补充至国家近红外快检模型库，用于基层药品快速检验。
目的：建立氯氮平片等56箇品種藥物的近紅外快速分析模型併進行驗證。方法：收集不同企業生產的藥物固體製劑，採集其近紅外漫反射光譜，建立定性分析模型，經不同人員採用不同儀器測定相同批次的樣品對建立的模型進行驗證。結果：所建定性分析模型均可以明確區分不同廠傢樣本，且篩查快速、準確。結論：所建模型可補充至國傢近紅外快檢模型庫，用于基層藥品快速檢驗。
목적：건립록담평편등56개품충약물적근홍외쾌속분석모형병진행험증。방법：수집불동기업생산적약물고체제제，채집기근홍외만반사광보，건립정성분석모형，경불동인원채용불동의기측정상동비차적양품대건립적모형진행험증。결과：소건정성분석모형균가이명학구분불동엄가양본，차사사쾌속、준학。결론：소건모형가보충지국가근홍외쾌검모형고，용우기층약품쾌속검험。
Objective: To set up a NIR method and validation system for rapid determination of 56 drugs. Methods:Solid pharmaceutical preparations from different manufacturers were collected, and their NIR spectra were obtained to set up the qualitative model.The same batch of samples was measured by different researchers with different instruments, and the model was verified.Results:The qualitative analysis model could clearly distinguish samples from different manufacturers and could be adopted for rapid and accurate drug screening. Conclusion:The method is rapid, simple and accurate. The established qualitative analysis model can be added to the national NIR model database and can be applied to rapid drug determination in the grassroots level.
