CAJ | 학술논문

目的：研究单指标中位数倍数（ multiple of median，MoM）值阈值和风险灰区对血清学产前筛查效能的影响。方法对石家庄市妇幼保健院2012年1月至2013年4月105899例孕妇孕中期唐氏综合征筛查结果进行甲胎蛋白（alphafetoprotein，AFP）、人绒毛膜促性腺激素（human chorionic gonadotropin，HCG）和游离雌三醇（ unconjugated estriol，uE3）的MoM值百分位数分析，21－三体风险灰区分析。结果最适合本实验室的单指标MoM值阈值是HCG MoM 2.70和uE3 MoM 0.50，风险灰区设置的效率偏低。结论实验室在考虑设置单MoM值阈值和灰区时，应在经验的基础上，再回顾历史数据，设置合理的阈值和灰区。
목적：연구단지표중위수배수（ multiple of median，MoM）치역치화풍험회구대혈청학산전사사효능적영향。방법대석가장시부유보건원2012년1월지2013년4월105899례잉부잉중기당씨종합정사사결과진행갑태단백（alphafetoprotein，AFP）、인융모막촉성선격소（human chorionic gonadotropin，HCG）화유리자삼순（ unconjugated estriol，uE3）적MoM치백분위수분석，21－삼체풍험회구분석。결과최괄합본실험실적단지표MoM치역치시HCG MoM 2.70화uE3 MoM 0.50，풍험회구설치적효솔편저。결론실험실재고필설치단MoM치역치화회구시，응재경험적기출상，재회고역사수거，설치합리적역치화회구。
Objective To explore the effect of single marker multiple of median( MoM) cutoff and risk grey-zone on screening efficiency.Methods A total of 105 899 serum screening sample results of second trimester pregnant women in Shijiazhuang Maternal and Child Health Hospital from Jan 2012 to Apr 2014 were selected, MoM of alphafetoprotein ( AFP) , human chorionic gonadotropin ( HCG) and unconjugated estriol ( uE3 ) were analyzed for percentile distribution and risk grey -zone distribution for trisomy of chromosome.Results A suitable single marker MoM cutoff for hCG and uE3 were 2.70 and 0.50.Due to the low efficiency, downs risk grey-zone was not preferable.Conclusion When laboratory applies single marker MoM cutoff and risk grey-zone, it should not only base on experience, but also review previous data to set a reasonable cutoff.