CAJ | 학술논문

目的：分析高危型人乳头瘤病毒（ high－risk human papillomavirus， HR－HPV）联合液基细胞学检测（ liquid－based cytology test， LCT）在宫颈癌前病变筛查中的临床价值。方法选择2010年7月至2014年7月在顺德区人口和计划生育服务中心及合作医院门诊行宫颈癌前病变筛查的1500名妇女，对其行HR－HPV及LCT并行病理活检，分析检测结果。结果 HR－HPV检测阴性1315例，阳性185例，阳性预测值为66.49％；LCT中无宫颈上皮内瘤变1330例，非典型鳞状上皮88例，低度鳞状上皮内病变41例，高度鳞状上皮内病变26例，鳞状细胞癌15例，阳性预测值为64.71％；HR－HPV联合LCT检测患者的敏感性为80.34％，高于HR－HPV组（60.59％）及LCT组（51.16％）（P＜0.05）。各检查方法的特异性、阳性预测值及阴性预测值比较，差异无统计学意义（ P＞0.05）。结论高危型HPV联合LCT检测用于筛查宫颈癌前病变具有较高的敏感性和特异性，有一定的临床参考意义。
목적：분석고위형인유두류병독（ high－risk human papillomavirus， HR－HPV）연합액기세포학검측（ liquid－based cytology test， LCT）재궁경암전병변사사중적림상개치。방법선택2010년7월지2014년7월재순덕구인구화계화생육복무중심급합작의원문진행궁경암전병변사사적1500명부녀，대기행HR－HPV급LCT병행병리활검，분석검측결과。결과 HR－HPV검측음성1315례，양성185례，양성예측치위66.49％；LCT중무궁경상피내류변1330례，비전형린상상피88례，저도린상상피내병변41례，고도린상상피내병변26례，린상세포암15례，양성예측치위64.71％；HR－HPV연합LCT검측환자적민감성위80.34％，고우HR－HPV조（60.59％）급LCT조（51.16％）（P＜0.05）。각검사방법적특이성、양성예측치급음성예측치비교，차이무통계학의의（ P＞0.05）。결론고위형HPV연합LCT검측용우사사궁경암전병변구유교고적민감성화특이성，유일정적림상삼고의의。
Objective To analyze the clinical value of high-risk human papillomavirus ( HR-HPV) detection combined with liquid-based cytology test ( LCT ) in precancerous cervical lesions screening.Methods A total of 1, 500 patients underwent precancerous cervical lesions screening in Shunde Population and Family Planning Service Center and Partner Hospitals from Jul 2010 to Jul 2014 were selected, who were dectected by HR-HPV, LCT and biopsy, the test results were analyzed.Results There were 1 315 cases HR-HPV negative patients, 185 positive patients, the positive predictive value was 66.49 %.There were 1 330 cases with no cervical intraepithelial neoplasia, 88 cases with atypical squamous cells ( ASC ) , 41 cases with low grade squamous intraepithelial neoplasia (LSIL), 26 cases with high grade squamous intraepithelial neoplasia (HSIL), 15 cases with squamous cell carcinoma ( SCC), the positive predictive value was 64.71 %.The sensitivity of HR -HPV detection combined with LCT was 80.34 %, which was significantly higher than that in HR-HPV group (60.59 %) and LCT group (51.16 %) (P<0.05), there was no significant difference in specificity, positive predictive value, negative predictive value between inspection methods ( P >0.05).Conclusion HR-HPV detection combined with LCT for cervical lesions screening has a high sensitivity and specificity with clinical reference value.