CAJ | 학술논문

目的：研究基层育龄人群地中海贫血（简称地贫）的干预模式。方法回顾性分析2013年10月至2014年10月英德地区7311对夫妇的调查资料，对地贫筛查结果及干预效果进行分析。结果共检出地贫高风险夫妇104对，检出率为1.42％；α地贫高风险夫妇共检出77对，检出率为1.05％；β地贫高风险夫妇共检出27对，检出率为0.37％；7311对夫妇中，检出HbH胎儿2例（0.03％），检出重型α地贫胎儿9例（0.12％），重型β地贫胎儿3例（0.04％）。干预后育龄人群的地贫知识明显高于干预前（P＜0.05）。结论建立完善的地贫筛查技术平台、工作流程、筛查流程及筛查网络，加强对医务人员及相关技术人员的培训，加大宣传力度和筛查力度，完善遗传咨询、跟踪随访制度能够有效的预防中重型地贫患儿的出生。
목적：연구기층육령인군지중해빈혈（간칭지빈）적간예모식。방법회고성분석2013년10월지2014년10월영덕지구7311대부부적조사자료，대지빈사사결과급간예효과진행분석。결과공검출지빈고풍험부부104대，검출솔위1.42％；α지빈고풍험부부공검출77대，검출솔위1.05％；β지빈고풍험부부공검출27대，검출솔위0.37％；7311대부부중，검출HbH태인2례（0.03％），검출중형α지빈태인9례（0.12％），중형β지빈태인3례（0.04％）。간예후육령인군적지빈지식명현고우간예전（P＜0.05）。결론건립완선적지빈사사기술평태、공작류정、사사류정급사사망락，가강대의무인원급상관기술인원적배훈，가대선전력도화사사력도，완선유전자순、근종수방제도능구유효적예방중중형지빈환인적출생。
Objective To study thalassemia intervention model for childbearing population in grassroots.Methods The data of 7 311 couples in Yingde region from Oct 2013 to Oct 2014 were retrospectively analyzed, and the screening results of thalassemia and intervention effects were analyzed.Results 104 couples were detected to have high risk with the positive rate at 1.42 %, and 77 couples were found to have αthalassemia high risk with the positive rate at 1.05 %, a total of 27 couples were found to have βthalassemia high risk with the positive rate at 0.37 %, 2 HbH fetuses (0.03 %) were detected among 311 couples, 9 fetuses (0.12 %) withαthalassemia, 3 fetuses withβthalassemia (0.04 %) were detected.The knowledge of reproductive population on thalassemia after the intervention was obviously higher than that before intervention ( P<0.05 ) .Conclusion The establishment of perfect thalassemia technology platform, work process, screening process and screening network, strengthening of training on medical personnel and related technical personnel, intensification of propaganda and screening and improvement of genetic counseling and follow-up system can effectively prevent the occurrence of heavy thalassemia infants.