CAJ | 학술논문

目的：探讨生殖免疫抗体对女性生育能力的影响。方法收集2013年8月至2014年7月在四川省妇幼保健院生殖医学中心就诊的1428例女性不孕症患者资料，采用酶联免疫吸附（ ELISA）方法进行生殖免疫抗体检测，分析生殖免疫抗体对女性生育能力的影响。结果有36.27％不孕症女性检测出抗体阳性，其中抗精子抗体（ AsAb）、抗卵巢抗体（ AOVAb）、抗子宫内膜抗体（ AEMAb）、抗hCG抗体（ AhCGAb）、抗心心磷脂抗体（ ACA－IgG）阳性率分别为10.15％、20.66％、7.35％、6.02％、9.66％；继发不孕和原发不孕生殖免疫抗体均以单个抗体阳性为主，分别占72.39％和71.95％，继发不孕AhCGAb、AsAb、AEMAb阳性率（7.30％、11.95％、8.90％）高于原发不孕（4.59％、8.15％、5.63％）（P＜0.05），输卵管阻塞者AOVAb、AEMAb、ACA－IgG阳性率（34.94％、9.94％、9.09％）高于输卵管通.者（11.28％、2.05％、2.56％）（ P＜0.05）。结论生殖免疫抗体是女性不孕症的重要影响因素，与既往妊娠史和输卵管阻塞有关，应加强生殖健康教育，减少非意愿妊娠人工流产和生殖道感染，降低罹患不孕症的风险。
목적：탐토생식면역항체대녀성생육능력적영향。방법수집2013년8월지2014년7월재사천성부유보건원생식의학중심취진적1428례녀성불잉증환자자료，채용매련면역흡부（ ELISA）방법진행생식면역항체검측，분석생식면역항체대녀성생육능력적영향。결과유36.27％불잉증녀성검측출항체양성，기중항정자항체（ AsAb）、항란소항체（ AOVAb）、항자궁내막항체（ AEMAb）、항hCG항체（ AhCGAb）、항심심린지항체（ ACA－IgG）양성솔분별위10.15％、20.66％、7.35％、6.02％、9.66％；계발불잉화원발불잉생식면역항체균이단개항체양성위주，분별점72.39％화71.95％，계발불잉AhCGAb、AsAb、AEMAb양성솔（7.30％、11.95％、8.90％）고우원발불잉（4.59％、8.15％、5.63％）（P＜0.05），수란관조새자AOVAb、AEMAb、ACA－IgG양성솔（34.94％、9.94％、9.09％）고우수란관통.자（11.28％、2.05％、2.56％）（ P＜0.05）。결론생식면역항체시녀성불잉증적중요영향인소，여기왕임신사화수란관조새유관，응가강생식건강교육，감소비의원임신인공유산화생식도감염，강저리환불잉증적풍험。
Objective To explore the impact of reproductive immune antibody on female infertility.Methods Clinical data of 1 428 cases with female infertility in Sichuan Provincial Hospital for Women and Children from Aug 2013 to Jul 2014 were collected, the reproductive immune antibody of all cases were tested by ELISA, and the impact of reproductive immune antibody on female fertility was analyzed.Results There were 36.27 % cases were detected antibody positive, the positive rates of AsAb, AOVAb, AEMAb, AhCGAb, and ACA-IgG were 10.15 %, 20.66 %, 7.35 %, 6.02 % and 9.66 % respectively.The single antibody positive dominated both in secondary and primary infertility, with the ratio of 72.39 % and 71.95 %.The positive rate of AhCGAb, AsAb, and AEMAb in secondary infertility(7.30 %,11.95 %,8.90 % respectively) were higher than that in primary infertility(4.59 %, 8.15 %,5.63 %respectively) (P<0.05).The positive rate of AOVAb, AEMAb, and ACA-IgG in cases with oviduct obstruction (34.94 %,9.94 %,9.09 %respectively) was higher than that without obstruction (11.28 %,2.05%,2.56%,respectively)(P<0.05).Conclusion Reproductive immune antibody plays a significant role in female infertility, which is related with previous pregnancy and oviduct obstruction.Therefore, it is imperative to strengthen reproductive health education as well as abate abortion caused by unwanted pregnancy and genital tract infection in order to reduce the risk of infertility.