CAJ | 학술논문

目的：观察小剂量雄激素联合中药治疗特发性少弱精子症的临床效果。方法选取2012～2013年在英德市人民医院就诊的214例特发性少弱精子症患者的临床资料，根据不同用药方法分为雄激素组和对照组，其中雄激素组136例，采用小剂量雄激素（安雄40 mg，2次／d）联合中药（复方玄驹胶囊1.26 g，3次／d）治疗；对照组78例单纯使用中药治疗。随访半年，观察两组对象的精液参数恢复情况、配偶妊娠情况。结果两组患者治疗后的精子总数[（55.48±8.23）、（54.03±12.42）百万／次]、前向运动精子总数[（32.78±4.68）、（32.08±4.89）百万／次]较治疗前的精子总数[（23.28±4.03）、（23.04±4.78）百万／次]、前向运动精子总数[（9.39±1.99）、（9.19±1.98）百万／次]均有改善（P＜0.05），但两组间治疗后的精子总数、前向运动精子总数比较，差异均无统计学意义（ P＞0.05）。雄激素组配偶妊娠率为11.03％（15／136），对照组为11.54％（9／78），两组间比较差异无统计学意义（P＞0.05）。结论小剂量雄激素联合中药与单独使用中药治疗特发性少弱精子症的临床效果无明显差异。
목적：관찰소제량웅격소연합중약치료특발성소약정자증적림상효과。방법선취2012～2013년재영덕시인민의원취진적214례특발성소약정자증환자적림상자료，근거불동용약방법분위웅격소조화대조조，기중웅격소조136례，채용소제량웅격소（안웅40 mg，2차／d）연합중약（복방현구효낭1.26 g，3차／d）치료；대조조78례단순사용중약치료。수방반년，관찰량조대상적정액삼수회복정황、배우임신정황。결과량조환자치료후적정자총수[（55.48±8.23）、（54.03±12.42）백만／차]、전향운동정자총수[（32.78±4.68）、（32.08±4.89）백만／차]교치료전적정자총수[（23.28±4.03）、（23.04±4.78）백만／차]、전향운동정자총수[（9.39±1.99）、（9.19±1.98）백만／차]균유개선（P＜0.05），단량조간치료후적정자총수、전향운동정자총수비교，차이균무통계학의의（ P＞0.05）。웅격소조배우임신솔위11.03％（15／136），대조조위11.54％（9／78），량조간비교차이무통계학의의（P＞0.05）。결론소제량웅격소연합중약여단독사용중약치료특발성소약정자증적림상효과무명현차이。
Objective To observe the clinical effect of low dose androgen combined with traditional Chinese medicine in the treatment of idiopathic oligoasthenospermia.Methods Clinical data of 214 patients with idiopathic oligoasthenospermia in The People’ s Hospital of Yingde City from 2012 to 2013 were selected.All cases were divided into testosterone group and control group, patients in testosterone group ( n=136 ) were given small dose of androgen ( male 40 mg, bid ) combined with traditional Chinese medicine(compound Xuanju capsule 1.26 g, tid), patients in control group (n=78) were given traditional Chinese medicine only. After 6 months followed-up, the semen parameters and recovery pregnancy situation of the two groups were observed.Results The total number of sperm and number of forward movement sperm after treatment [ ( 55.48 ±8.23 ) million, ( 54.03 ±12.42 ) million;(32.78 ±4.68)million,(32.08 ±4.89)million respectively] improved than those before treatment[(12.28 ±4.03)million,(23.04 ±4.98)million;(9.39 ±1.99) million,(9.19 ±1.98) million respectively] in both groups ( P <0.05).The difference in total number of sperm and number of forward movement sperm after treatment between two groups had no significance ( P>0.05 ) .The pregnancy rate of the androgen group was 11.03 % ( 15/136 ) , while the control group was 11.54 % ( 9/78 ) , there was no statistically significant difference between two groups ( P>0.05) .Conclusion The small dose of androgen combined with traditional Chinese medicine and traditional Chinese medicine alone show no significant difference in treatment of idiopathic asthenospermia.