蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
6期
798-799,800
,共3页
紫癜,血小板减少性%T淋巴细胞%B淋巴细胞%自然杀伤细胞
紫癜,血小闆減少性%T淋巴細胞%B淋巴細胞%自然殺傷細胞
자전,혈소판감소성%T림파세포%B림파세포%자연살상세포
purura,idiopathic thrombocytopenic%T lymphocyte%B lymphocyte%natural killer cell
目的：：儿童分析特发性血小板减少性紫癜( ITP)外周血淋巴细胞亚群的变化。方法：应用流式细胞术,分别检测85例ITP患儿( ITP组)和32名健康体检儿童(对照组)淋巴细胞亚群。结果：与对照组相比,ITP组患儿外周血CD3+和CD4+细胞数量减少,CD4+/CD8+比值下降(P<0.01)；CD8+细胞与对照组差异无意义(P>0.05)。 CD19+细胞较对照组明显增多, CD16+CD56+细胞较对照组减少(P<0.01)。结论：ITP患儿淋巴细胞亚群与正常儿童存在差异,淋巴细胞亚群紊乱是儿童ITP发生的免疫机制之一。
目的：：兒童分析特髮性血小闆減少性紫癜( ITP)外週血淋巴細胞亞群的變化。方法：應用流式細胞術,分彆檢測85例ITP患兒( ITP組)和32名健康體檢兒童(對照組)淋巴細胞亞群。結果：與對照組相比,ITP組患兒外週血CD3+和CD4+細胞數量減少,CD4+/CD8+比值下降(P<0.01)；CD8+細胞與對照組差異無意義(P>0.05)。 CD19+細胞較對照組明顯增多, CD16+CD56+細胞較對照組減少(P<0.01)。結論：ITP患兒淋巴細胞亞群與正常兒童存在差異,淋巴細胞亞群紊亂是兒童ITP髮生的免疫機製之一。
목적：：인동분석특발성혈소판감소성자전( ITP)외주혈림파세포아군적변화。방법：응용류식세포술,분별검측85례ITP환인( ITP조)화32명건강체검인동(대조조)림파세포아군。결과：여대조조상비,ITP조환인외주혈CD3+화CD4+세포수량감소,CD4+/CD8+비치하강(P<0.01)；CD8+세포여대조조차이무의의(P>0.05)。 CD19+세포교대조조명현증다, CD16+CD56+세포교대조조감소(P<0.01)。결론：ITP환인림파세포아군여정상인동존재차이,림파세포아군문란시인동ITP발생적면역궤제지일。
Objective:To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura(ITP). Methods:The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry. Results:The percentages of CD3 + and CD4 + and the ratio of CD4/CD8 in ITP group were lower than those in control group(P<0. 01),and the difference of CD8 + lymphocyte between two groups was not statistically significant(P>0. 05). Compared with the control group,the number of CD19 + and CD16 +CD56 + lymphocytes in ITP group increased and decreased,respectively,the differences of whose between two groups were statistically significant(P<0. 01). Conclusions:The disorder of lymphocyte subsets is one of the immune mechanism of ITP occurrence in children. Correcting disorder will be conducive to the treatment.
