蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
6期
746-748
,共3页
冠心病%阿托伐他汀%冠状动脉搭桥术%血脂%心功能
冠心病%阿託伐他汀%冠狀動脈搭橋術%血脂%心功能
관심병%아탁벌타정%관상동맥탑교술%혈지%심공능
coronary artery disease%atorvastatin%coronary artery bypass grafting%lipid%cardiac function
目的：：观察冠心病冠状动脉搭桥术( CABG)患者治疗前后应用不同剂量阿托伐他汀对术后血脂及心功能的影响。方法：将60例拟行CABG治疗的冠心病患者根据手术前后阿托伐他汀使用的剂量不同分为强化治疗组(40 mg/d)和常规治疗组(20 mg/d)各30例。比较2组患者治疗前后血脂及超声心动图检查结果，并记录用药期间不良反应。结果：强化治疗组治疗后总胆固醇、三酰甘油和低密度脂蛋白胆固醇降低程度及高密度脂蛋白胆固醇升高程度均优于常规治疗组( P<0.05~P<0.01)。强化治疗组治疗后左心室收缩末期容积指数、左心室舒张末期容积指数和A峰降低程度及E峰、E/A与左心室射血分数升高程度均优于常规治疗组(P<0.01)。强化治疗组总不良反应率为16.67%，常规治疗组为10.00%，差异无统计学意义(P>0.05)。结论：冠心病CABG患者治疗前后应用阿托伐他汀强化治疗可显著调节血脂、改善心功能，效果优于常规剂量，且并不增加不良反应，安全有效。
目的：：觀察冠心病冠狀動脈搭橋術( CABG)患者治療前後應用不同劑量阿託伐他汀對術後血脂及心功能的影響。方法：將60例擬行CABG治療的冠心病患者根據手術前後阿託伐他汀使用的劑量不同分為彊化治療組(40 mg/d)和常規治療組(20 mg/d)各30例。比較2組患者治療前後血脂及超聲心動圖檢查結果，併記錄用藥期間不良反應。結果：彊化治療組治療後總膽固醇、三酰甘油和低密度脂蛋白膽固醇降低程度及高密度脂蛋白膽固醇升高程度均優于常規治療組( P<0.05~P<0.01)。彊化治療組治療後左心室收縮末期容積指數、左心室舒張末期容積指數和A峰降低程度及E峰、E/A與左心室射血分數升高程度均優于常規治療組(P<0.01)。彊化治療組總不良反應率為16.67%，常規治療組為10.00%，差異無統計學意義(P>0.05)。結論：冠心病CABG患者治療前後應用阿託伐他汀彊化治療可顯著調節血脂、改善心功能，效果優于常規劑量，且併不增加不良反應，安全有效。
목적：：관찰관심병관상동맥탑교술( CABG)환자치료전후응용불동제량아탁벌타정대술후혈지급심공능적영향。방법：장60례의행CABG치료적관심병환자근거수술전후아탁벌타정사용적제량불동분위강화치료조(40 mg/d)화상규치료조(20 mg/d)각30례。비교2조환자치료전후혈지급초성심동도검사결과，병기록용약기간불량반응。결과：강화치료조치료후총담고순、삼선감유화저밀도지단백담고순강저정도급고밀도지단백담고순승고정도균우우상규치료조( P<0.05~P<0.01)。강화치료조치료후좌심실수축말기용적지수、좌심실서장말기용적지수화A봉강저정도급E봉、E/A여좌심실사혈분수승고정도균우우상규치료조(P<0.01)。강화치료조총불량반응솔위16.67%，상규치료조위10.00%，차이무통계학의의(P>0.05)。결론：관심병CABG환자치료전후응용아탁벌타정강화치료가현저조절혈지、개선심공능，효과우우상규제량，차병불증가불량반응，안전유효。
Objective:To explore the effects of different doses of atorvastatin on the cardiac function and lipid in the patients with coronary heart disease after coronary artery bypass grafting( CABG) . Methods:Sixty patients with coronary artery disease scheduled by CABG were randomly divided into the intensive treatment group(40 mg/d) and conventional treatment group(20 mg/d) according to the dose of atorvastatn before and after the surgery(30 cases each group). The blood lipid level and echocardiographic finding between two groups were compared before and after surgery,and the adverse reactions in two groups were recorded during treatment. Results:After treatment,the reduction of total cholesterol,triglyceride and low-density lipoprotein-cholesterol and increasing degree of high-density lipoprotein-cholesterol in intensive treatment group were better than those in conventional treatment group(P <0. 05 to P <0. 01). After treatment,the reduction of left ventricular end systolic volume index,left ventricular end-diastolic volume index and A peak and increasing degree of E peak,E/A and left ventricular ejection fraction in intensive treatment group were better than those in conventional treatment group(P<0. 01). The adverse reaction rates in intensive treatment group and conventional treatment group were 16. 67% and 10. 00%,respectively,the difference of which was not statistically significant(P>0. 05). Conclusions:The application of atorvastatin in the treatment of the coronary heart disease patients treated with CABG before and after surgery can significantly regulate blood lipid and improve heart function,which does not increase adverse reactions,and is safe and effective.
