CAJ | 학술논문

目的：探讨短期吸食海洛因和冰毒者戒断后静息态下脑低频振幅(ALFF)的差异。方法对16例男性短期吸食海洛因者和14例男性短期吸食冰毒者进行静息态功能磁共振成像(fMRI)扫描，将获得的脑功能数据通过预处理软件获得 ALFF 图像，观察2组间图像的差异。阈值设为0.05。结果与冰毒组比较，海洛因组 ALFF 升高的脑区为左侧舌回，左侧小脑扁桃体；ALFF 减低的脑区为左侧脑干，中脑，左侧小脑蚓部。结论短期海洛因吸食者和冰毒吸食者戒断后脑功能存在差异，差异主要位于认知和情感系统。
목적：탐토단기흡식해락인화빙독자계단후정식태하뇌저빈진폭(ALFF)적차이。방법대16례남성단기흡식해락인자화14례남성단기흡식빙독자진행정식태공능자공진성상(fMRI)소묘，장획득적뇌공능수거통과예처리연건획득 ALFF 도상，관찰2조간도상적차이。역치설위0.05。결과여빙독조비교，해락인조 ALFF 승고적뇌구위좌측설회，좌측소뇌편도체；ALFF 감저적뇌구위좌측뇌간，중뇌，좌측소뇌인부。결론단기해락인흡식자화빙독흡식자계단후뇌공능존재차이，차이주요위우인지화정감계통。
Objective To investigate the differences of low frequency fluctuation (ALFF)in the resting state between short-term heroin and methamphetamine abusers after withdrawal.Methods Sixteen male short-term heroin abusers and fourteen male short-term methamphetamine abusers were performed the functional magnetic resonance imaging (fMRI).The differences of ALFF be-tween the two groups were performed with preprocessing softwares.Threshold was set to 0.05.Results Compared with metham-phetamine-dependent patients,heroin-dependent patients showed increased ALFF in the left side of the lingual gyrus and the left ton-sil of cerebellum and decreased ALFF in the left side of the brain stem,midbrain and the left side of the cerebellar vermis.Conclusion There are differences between the short-term heroin and methamphetamine abusers in the function of the brain,mainly involving the brain regions associating with cognition and affection.