CAJ | 학술논문

目的：观察利格列汀联合二甲双胍对初发2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者的临床疗效。方法35例初发2型糖尿病合并 NAFLD 患者随机分为2组,在生活方式干预治疗基础上,治疗组给予二甲双胍500 mg,tid,口服；利格列汀5 mg,qd,口服,对照组给予二甲双胍500 mg,tid,口服治疗16周后,根据体征、肝脏 B 超和各项生化指标判断两组患者的疗效,记录不良事件。结果与治疗前比较,两组患者各项指标明显改善(P<0.05)；与对照组比较,治疗组肝酶糖化血红蛋白胰岛素抵抗指数甘油三酯改善更明显(P<0.05),两组患者脂肪肝疗效比较,治疗组有效率为83%,对照组有效率为29%,差异有统计学意义(P<0.01),两组不良反应差异无统计学意义(P>0.05)。结论利格列汀联合二甲双胍是一种新型安全有效的 T2DM 合并 NAFLD 的治疗方案。
목적：관찰리격렬정연합이갑쌍고대초발2형당뇨병(T2DM)합병비주정성지방간(NAFLD)환자적림상료효。방법35례초발2형당뇨병합병 NAFLD 환자수궤분위2조,재생활방식간예치료기출상,치료조급여이갑쌍고500 mg,tid,구복；리격렬정5 mg,qd,구복,대조조급여이갑쌍고500 mg,tid,구복치료16주후,근거체정、간장 B 초화각항생화지표판단량조환자적료효,기록불량사건。결과여치료전비교,량조환자각항지표명현개선(P<0.05)；여대조조비교,치료조간매당화혈홍단백이도소저항지수감유삼지개선경명현(P<0.05),량조환자지방간료효비교,치료조유효솔위83%,대조조유효솔위29%,차이유통계학의의(P<0.01),량조불량반응차이무통계학의의(P>0.05)。결론리격렬정연합이갑쌍고시일충신형안전유효적 T2DM 합병 NAFLD 적치료방안。
Objective To observe the clinical efficacy of linagliptin combined with metformin in the treatment of patients of newly diagnosed type 2 diabetes mellitus (T2DM) accompanying non-alcoholic fatty liver disease ( NAFLD). Methods 35 patients with T2DM accompanying NAFLD were randomly divided into two groups. the treatment group was treated with metformin (500 mg,tid) plus linagliptin (5 mg,qd) and the control group was treated with metformin (500 mg,tid) on the basis of li-festyle intervention therapy. After treatment for 16 weeks,The therapeutic effectiveness in two group was analyzed by synthetic judgment according to physical signs ,B- ultrasonic examination in liver and biochemical laboratory results,and adverse events were recorded. Results Compared with before treatment, there were significant difference in two groups(P<0. 05), Compared with control group, The improvements of liver enzyme,glycosylated hemoglobin (HbA1c) ,insulin resistance index (HOMA-IR),triglyceride (TG) in treatment group were better than those in control group (P<0. 05). As to the efficacy of fatty liver,the general efficiency of treatment group was 89% while 29% of control group, the difference was significant (P<0. 01). Adverse events had no significant difference be-tween the two groups(P>0. 05). Conclusion Linagliptin combined with metformin is a new kind of safe and effective treatment for T2DM accompanying NAFLD.