哈尔滨医药
哈爾濱醫藥
합이빈의약
HARBIN MEDICAL JOURNAL
2015年
3期
192-194
,共3页
小儿%支气管肺炎%炎症因子
小兒%支氣管肺炎%炎癥因子
소인%지기관폐염%염증인자
Children%Bronchopneumonia%Inflammatory cytokines
目的：探讨小儿支气管肺炎的相关炎症因子水平变化情况。方法将90例小儿支气管肺炎患儿分为重症支气管肺炎组(n=36例),轻型支气管肺炎组( n =54例),选取同期在我院进行健康体检儿童40例作为对照组进行对照研究。结果治疗前重症支气管肺炎组、轻型支气管肺炎组及健康对照组受检者的 WBC、CPR 及 PCT 水平逐渐下降,两两比较均 P<0.001；治疗后两组患儿的 WBC、CRP、IL-6及 PCT 水平均显著低于治疗前,P<0.001；重症支气管炎患儿治疗前及治疗后的 WBC、CRP、IL-6及 PCT 水平均显著高于轻型支气管肺炎组患儿同期水平,P<0.001；重症支气管肺炎的 CRP 与 IL-6(r=0.619),CRP 与 PCT(r=0.442),IL-6与 PCT(0.390)均存在明显的正相关性,P<0.05；轻型支气管肺炎的 CRP 与 IL-6(r=0.582),CRP 与 PCT(r=0.420),IL-6与 PCT(r=0.324)均存在明显的正相关性,P<0.05。肺炎患儿的 WBC 与 CRP、IL-6及PCT 无明显相关性,P>0.05。结论小儿支气管肺炎 CRP、IL-6及 PCT 水平测定可作为炎症强弱及肺炎严重程度的预警指标,对于指导治疗及预后判断有一定的帮助。
目的：探討小兒支氣管肺炎的相關炎癥因子水平變化情況。方法將90例小兒支氣管肺炎患兒分為重癥支氣管肺炎組(n=36例),輕型支氣管肺炎組( n =54例),選取同期在我院進行健康體檢兒童40例作為對照組進行對照研究。結果治療前重癥支氣管肺炎組、輕型支氣管肺炎組及健康對照組受檢者的 WBC、CPR 及 PCT 水平逐漸下降,兩兩比較均 P<0.001；治療後兩組患兒的 WBC、CRP、IL-6及 PCT 水平均顯著低于治療前,P<0.001；重癥支氣管炎患兒治療前及治療後的 WBC、CRP、IL-6及 PCT 水平均顯著高于輕型支氣管肺炎組患兒同期水平,P<0.001；重癥支氣管肺炎的 CRP 與 IL-6(r=0.619),CRP 與 PCT(r=0.442),IL-6與 PCT(0.390)均存在明顯的正相關性,P<0.05；輕型支氣管肺炎的 CRP 與 IL-6(r=0.582),CRP 與 PCT(r=0.420),IL-6與 PCT(r=0.324)均存在明顯的正相關性,P<0.05。肺炎患兒的 WBC 與 CRP、IL-6及PCT 無明顯相關性,P>0.05。結論小兒支氣管肺炎 CRP、IL-6及 PCT 水平測定可作為炎癥彊弱及肺炎嚴重程度的預警指標,對于指導治療及預後判斷有一定的幫助。
목적：탐토소인지기관폐염적상관염증인자수평변화정황。방법장90례소인지기관폐염환인분위중증지기관폐염조(n=36례),경형지기관폐염조( n =54례),선취동기재아원진행건강체검인동40례작위대조조진행대조연구。결과치료전중증지기관폐염조、경형지기관폐염조급건강대조조수검자적 WBC、CPR 급 PCT 수평축점하강,량량비교균 P<0.001；치료후량조환인적 WBC、CRP、IL-6급 PCT 수평균현저저우치료전,P<0.001；중증지기관염환인치료전급치료후적 WBC、CRP、IL-6급 PCT 수평균현저고우경형지기관폐염조환인동기수평,P<0.001；중증지기관폐염적 CRP 여 IL-6(r=0.619),CRP 여 PCT(r=0.442),IL-6여 PCT(0.390)균존재명현적정상관성,P<0.05；경형지기관폐염적 CRP 여 IL-6(r=0.582),CRP 여 PCT(r=0.420),IL-6여 PCT(r=0.324)균존재명현적정상관성,P<0.05。폐염환인적 WBC 여 CRP、IL-6급PCT 무명현상관성,P>0.05。결론소인지기관폐염 CRP、IL-6급 PCT 수평측정가작위염증강약급폐염엄중정도적예경지표,대우지도치료급예후판단유일정적방조。
Objective To explore the changes of the related inflammatory factors level in Children with bronchial pneumonia. Methods 90 cases of Children with bronchial pneumonia were divided into the severe bronchial pneumonia group (n= 36patients), Light bronchial pneumonia group (n=54patients). select 40 cases of Health examination children in our hospital in the same period as the control group. Results The WBC、CRP、PCT in the severe bronchial pneumonia group, Light bronchial pneumonia group and the control group were graduallyfall. Pairwise comparisons were P<0. 001. the CRP, IL-6 and PCT levels in the severe bronchial pneu-monia group were significantly higher than that in the Light bronchial pneumonia group, P<0. 001. the CRP and IL-6 (r=0. 619), CRP and PCT (r=0. 442), IL-6 and PCT(0. 390) presence significant positive correlation in the severe bronchial pneumonia group. P<0. 05. the CRP and IL-6 (r=0. 582), CRP and PCT (r=0. 420), IL-6 and PCT (r=0. 324) presence significant positive corre-lation in the the light bronchial pneumonia group. P<0. 05. the wbc compared with CRP, IL-6 and PCT didn't presence significant positive correlation in children with bronchial pneumonia. Conclusion The CRP, IL-6 and PCT levels measured in Children with bronchial pneumonia could as the intensity and extent of the pneumonia severity . and early warning indicators of inflammation,there is some help for guiding treatment and prognosis.
