中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2015年
12期
918-920
,共3页
脑性瘫痪%语言发育迟缓%扩散张量成像%语言功能区
腦性癱瘓%語言髮育遲緩%擴散張量成像%語言功能區
뇌성탄탄%어언발육지완%확산장량성상%어언공능구
Cerebral palsy%Language development delay%Diffusion tensor imaging%Language functional areas
目的 利用扩散张量成像(DTI)技术测定脑性瘫痪(脑瘫)合并语言发育迟缓患儿语言相关脑区(Broca区、Wernicke区、弓状纤维束)的各向异性参数(FA),探讨脑瘫患儿语言发育迟缓的发病机制.方法 采用Philips 3.0T磁共振仪,对27例脑瘫合并语言发育迟缓患儿(观察组)和20例热性惊厥患儿(对照组)行DTI扫描,于Philips磁共振自带工作站进行后处理,计算Broca区、Wernicke区及弓状纤维束的FA值.结果 对照组患儿左侧Broca区、Wernicke区及弓状纤维束的FA值均高于右侧,差异均有统计学意义(P均＜0.05).观察组患儿左侧Broca区的FA值低于右侧,差异有统计学意义(P＜0.05);左侧Wernicke区及弓状纤维束的FA值均高于右侧,但差异无统计学意义(P均＞0.05).观察组Broca区、Broca镜像区及两侧弓状纤维束的FA值低于对照组,差异有统计学意义(P＜ 0.05),Wernick区及Wernick镜像区的FA值也低于对照组,但差异均无统计学意义(P均＞0.05).结论 脑瘫患儿语言发育迟缓的主要发病机制为语言相关脑区的广泛性损伤,Broca区及弓状纤维束受损较Wernick区明显.
目的 利用擴散張量成像(DTI)技術測定腦性癱瘓(腦癱)閤併語言髮育遲緩患兒語言相關腦區(Broca區、Wernicke區、弓狀纖維束)的各嚮異性參數(FA),探討腦癱患兒語言髮育遲緩的髮病機製.方法 採用Philips 3.0T磁共振儀,對27例腦癱閤併語言髮育遲緩患兒(觀察組)和20例熱性驚厥患兒(對照組)行DTI掃描,于Philips磁共振自帶工作站進行後處理,計算Broca區、Wernicke區及弓狀纖維束的FA值.結果 對照組患兒左側Broca區、Wernicke區及弓狀纖維束的FA值均高于右側,差異均有統計學意義(P均＜0.05).觀察組患兒左側Broca區的FA值低于右側,差異有統計學意義(P＜0.05);左側Wernicke區及弓狀纖維束的FA值均高于右側,但差異無統計學意義(P均＞0.05).觀察組Broca區、Broca鏡像區及兩側弓狀纖維束的FA值低于對照組,差異有統計學意義(P＜ 0.05),Wernick區及Wernick鏡像區的FA值也低于對照組,但差異均無統計學意義(P均＞0.05).結論 腦癱患兒語言髮育遲緩的主要髮病機製為語言相關腦區的廣汎性損傷,Broca區及弓狀纖維束受損較Wernick區明顯.
목적 이용확산장량성상(DTI)기술측정뇌성탄탄(뇌탄)합병어언발육지완환인어언상관뇌구(Broca구、Wernicke구、궁상섬유속)적각향이성삼수(FA),탐토뇌탄환인어언발육지완적발병궤제.방법 채용Philips 3.0T자공진의,대27례뇌탄합병어언발육지완환인(관찰조)화20례열성량궐환인(대조조)행DTI소묘,우Philips자공진자대공작참진행후처리,계산Broca구、Wernicke구급궁상섬유속적FA치.결과 대조조환인좌측Broca구、Wernicke구급궁상섬유속적FA치균고우우측,차이균유통계학의의(P균＜0.05).관찰조환인좌측Broca구적FA치저우우측,차이유통계학의의(P＜0.05);좌측Wernicke구급궁상섬유속적FA치균고우우측,단차이무통계학의의(P균＞0.05).관찰조Broca구、Broca경상구급량측궁상섬유속적FA치저우대조조,차이유통계학의의(P＜ 0.05),Wernick구급Wernick경상구적FA치야저우대조조,단차이균무통계학의의(P균＞0.05).결론 뇌탄환인어언발육지완적주요발병궤제위어언상관뇌구적엄범성손상,Broca구급궁상섬유속수손교Wernick구명현.
Objective To measure the fractional anisotropy(FA) values in the language function areas(Broca area,Wernicke area and arcuate fasciculus)by diffusion tensor imaging(DTI),discussing the pathological characteristics in cerebral palsy children with language development delay.Methods DTI was performed in twenty-seven cerebral palsy children with language development delay(observation group) and 20 children with febrile seizures(control group) by Philips 3.0T MRI scanner.The FA values of Broca area,Wernicke area and arcuate fasciculus were measured at Philips Workstation.Results The FA values of control group in the left Broca area,Wernicke area and arcuate fasciculusis were higher than those of the right side,and the difference was statistically significant (all P ＜ 0.05).The FA value of observation group in the left Broca area was lower than that of the right side,and the difference was statistically significant (P ＜ 0.05);the FA values of observation group in the left Wernick area and arcuate fasciculusis were higher than those of the right side,but the difference was not statistically significance (all P ＞ 0.05).The FA values in the bilateral Broca area and arcuate fasciculusis of observation group were lower than those of the control group,the difference was statistically significant (P ＜ 0.05),those in the bilateral Wernick area were also lower than the control group,but the difference was not statistically significant (P ＞ 0.05).Conclusions The main pathogenesis for language development delay in cerebral palsy children was extensive damage in language functional areas,and Broca area and arcuate fasciculus were markedly impaired than Wernick area.
