CAJ | 학술논문

目的：观察已采用艾塞那肽及二甲双胍联合治疗的新诊断的肥胖2型糖尿病患者，空腹血糖控制不达标时加用地特胰岛素后的治疗效果。方法：选取2010年2月-2013年10月在我科门诊及住院新诊断的肥胖2型糖尿病患者中经艾塞那肽10μg，早晚餐前60 min皮下注射，二甲双胍1.0 g每天2次联合治疗4周后空腹血糖不达标者共22例，予加用地特胰岛素睡前皮下注射治疗，依据血糖控制目标调整地特胰岛素用量，治疗8周。观察血糖及体质量等变化情况。结果：患者加用地特胰岛素治疗8周后空腹血糖达标（P＜0.05），餐后血糖水平进一步下降（P＞0.05），体质量持续下降。结论：对于艾塞那肽联合二甲双胍治疗后空腹血糖不达标的肥胖2型糖尿病患者，加用地特胰岛素后可显著改善空腹血糖水平且未增加体质量。
목적：관찰이채용애새나태급이갑쌍고연합치료적신진단적비반2형당뇨병환자，공복혈당공제불체표시가용지특이도소후적치료효과。방법：선취2010년2월-2013년10월재아과문진급주원신진단적비반2형당뇨병환자중경애새나태10μg，조만찬전60 min피하주사，이갑쌍고1.0 g매천2차연합치료4주후공복혈당불체표자공22례，여가용지특이도소수전피하주사치료，의거혈당공제목표조정지특이도소용량，치료8주。관찰혈당급체질량등변화정황。결과：환자가용지특이도소치료8주후공복혈당체표（P＜0.05），찬후혈당수평진일보하강（P＞0.05），체질량지속하강。결론：대우애새나태연합이갑쌍고치료후공복혈당불체표적비반2형당뇨병환자，가용지특이도소후가현저개선공복혈당수평차미증가체질량。
Objective: To investigate the clinical efifcacy of exenatide combined with insulin detemir in newly diagnosed obesity patients with type 2 diabetes.Methods: 22 cases of newly diagnosed obesity patients with type 2 diabetes were choosed, who had been treated with exenatide and metformin for 4 weeks and their fasting blood glucose (FBG) were higher than the control target. They were treated with exenatide, metformin and insulin detemir for 8 weeks to observe the changes of blood glucose and weight.Results: After combined insulin detemir for 8 weeks, the fasting blood glucose was controlled well and the 2 hours postprandial blood glu-cose and weight were decreased continuously.Conclusion: The therapy with exenatide and insulin detemir can be used by obese patients with type 2 diabetes.