温州医科大学学报
溫州醫科大學學報
온주의과대학학보
Journal of Wenzhou Medical University
2015年
6期
449-451
,共3页
肺肿瘤%灌注%体层摄影术,X线计算机
肺腫瘤%灌註%體層攝影術,X線計算機
폐종류%관주%체층섭영술,X선계산궤
lung neoplasms%perfusion%tomography,x-ray computed
目的:探讨多层螺旋CT灌注成像对肺炎性结节与肺癌的鉴别价值。方法:选取2010年6月至2013年6月在我院欲行手术切除的孤立肺结节患者,先行肺部结节CT灌注成像检查,通过灌注软件计算肺癌和肺炎性结节患者的灌注参数,包括血容量(BV)、血流量(BF)、表面渗透系数(PS)和平均通过时间(MTT),并测量强化峰值(PH)、达峰值时间(TTP)、结节-主动脉强化峰值比(PHSPN/PHAA);用Mann-Whitney法比较2组间参数有无差异。结果:32例患者中肺癌26例和炎性结节6例,炎性结节组BF、PH、PHSPN/PHAA均大于肺癌结节组,差异有统计学意义(P<0.05)。炎性结节组与肺癌结节组的BV、PS差异无统计学意义(P>0.05)。以BF=78 mL·min-1·100 g-1作为炎性和肺癌结节区分阈值,其敏感度为88.5%,特异度为100%,阳性预测值为100%,阴性预测值为66.7%,准确度为90.6%。以PHSPN/PHAA=8.5%作为炎性和肺癌结节区分阈值,其敏感度为80.8%,特异度为83.3%,阳性预测值为95.5%,阴性预测值为50.0%,准确度为81.3%。结论:CT灌注成像对炎性结节及肺癌具有一定的鉴别价值。
目的:探討多層螺鏇CT灌註成像對肺炎性結節與肺癌的鑒彆價值。方法:選取2010年6月至2013年6月在我院欲行手術切除的孤立肺結節患者,先行肺部結節CT灌註成像檢查,通過灌註軟件計算肺癌和肺炎性結節患者的灌註參數,包括血容量(BV)、血流量(BF)、錶麵滲透繫數(PS)和平均通過時間(MTT),併測量彊化峰值(PH)、達峰值時間(TTP)、結節-主動脈彊化峰值比(PHSPN/PHAA);用Mann-Whitney法比較2組間參數有無差異。結果:32例患者中肺癌26例和炎性結節6例,炎性結節組BF、PH、PHSPN/PHAA均大于肺癌結節組,差異有統計學意義(P<0.05)。炎性結節組與肺癌結節組的BV、PS差異無統計學意義(P>0.05)。以BF=78 mL·min-1·100 g-1作為炎性和肺癌結節區分閾值,其敏感度為88.5%,特異度為100%,暘性預測值為100%,陰性預測值為66.7%,準確度為90.6%。以PHSPN/PHAA=8.5%作為炎性和肺癌結節區分閾值,其敏感度為80.8%,特異度為83.3%,暘性預測值為95.5%,陰性預測值為50.0%,準確度為81.3%。結論:CT灌註成像對炎性結節及肺癌具有一定的鑒彆價值。
목적:탐토다층라선CT관주성상대폐염성결절여폐암적감별개치。방법:선취2010년6월지2013년6월재아원욕행수술절제적고립폐결절환자,선행폐부결절CT관주성상검사,통과관주연건계산폐암화폐염성결절환자적관주삼수,포괄혈용량(BV)、혈류량(BF)、표면삼투계수(PS)화평균통과시간(MTT),병측량강화봉치(PH)、체봉치시간(TTP)、결절-주동맥강화봉치비(PHSPN/PHAA);용Mann-Whitney법비교2조간삼수유무차이。결과:32례환자중폐암26례화염성결절6례,염성결절조BF、PH、PHSPN/PHAA균대우폐암결절조,차이유통계학의의(P<0.05)。염성결절조여폐암결절조적BV、PS차이무통계학의의(P>0.05)。이BF=78 mL·min-1·100 g-1작위염성화폐암결절구분역치,기민감도위88.5%,특이도위100%,양성예측치위100%,음성예측치위66.7%,준학도위90.6%。이PHSPN/PHAA=8.5%작위염성화폐암결절구분역치,기민감도위80.8%,특이도위83.3%,양성예측치위95.5%,음성예측치위50.0%,준학도위81.3%。결론:CT관주성상대염성결절급폐암구유일정적감별개치。
Objective: To evaluate the value of computed tomography perfusion imaging in distinguishing inlfammatory and malignant nodules.Methods: CT perfusion scans were performed in patients with lung nodule received CT perfusion between September 2010 and February 2013. Patients with lung cancer and/or inlfamma-tory nodule were conifrmed by operation and proved by pathology. The parameters of CT perfusion, including blood volume (BV), blood lfow (BF), permeability-surface area product (PS), mean transit time (MTT) were pro-duced by perfusion software, and peak high (PH), time to peak (TTP), PHSPN/PHAA were measured. CTP parame-ters between above subgroups were analyzed using Mann-Whitney test.Results: Thirty-two cases were effective, including 26 cases of lung cancer and 6 cases of inlfammatory nodule. Inlfammatory nodules had higher BF, PH, PHSPN/PHAA than lung cancers (P<0.05). SPNS with BF larger than 78 mL ? min-1 ? 100 g-1 or PHSPN/PHAA larger than 8.5% were more likely to be inlfammatory (sensitivity of 88.5%, speciifcity of 100%, PPV of 100%, NPV of 66.7% and accuracy of 90.6% for BF; sensitivity of 80.8%, speciifcity of 83.3%, PPV of 95.5%, NPV of 50.0% and accuracy of 81.3% for PHSPN/PHAA).Conclusion: The CT pulmonary perfusion imaging is of some differ-ential role in distinguishing the inlfammatory nodule and malignant nodule.