CAJ | 학술논문

目的：探讨帕金森病合并快速动眼期异态睡眠（RBD）与认知功能障碍之间的关系。方法：收集2012年5月至2014年11月就诊于我院神经内科的54例帕金森病患者，其中帕金森病合并RBD组（PD-RBD组）25例，未合并RBD组（PD-NRBD组）29例，另收集社区健康对照组21例。所有受试者均完成2夜整夜视频多导睡眠监测、统一帕金森病量表III（UP-DRSIII）、Hoehn-Yahr分期、蒙特利尔认知评估量表（MoCA）、爱泼沃斯思睡量表（ESS）的评测。结果：①PD-RBD组注意力与计算力、视空间及执行功能、延迟记忆的得分明显低于PD-NRBD组和健康对照组，差异有统计学意义（均P＜0.05）；②PD-RBD组和PD-NRBD组睡眠效率较健康对照组低，合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）及不宁腿综合征发病率高，差异有统计学意义（P＜0.05）；③PD-RBD组和PD-NRBD组间睡眠效率及其他睡眠合并症差异无统计学意义（P＞0.05）。结论：帕金森病患者合并RBD与认知功能障碍相关，RBD可以作为帕金森病患者认知功能障碍的预测因素。
목적：탐토파금삼병합병쾌속동안기이태수면（RBD）여인지공능장애지간적관계。방법：수집2012년5월지2014년11월취진우아원신경내과적54례파금삼병환자，기중파금삼병합병RBD조（PD-RBD조）25례，미합병RBD조（PD-NRBD조）29례，령수집사구건강대조조21례。소유수시자균완성2야정야시빈다도수면감측、통일파금삼병량표III（UP-DRSIII）、Hoehn-Yahr분기、몽특리이인지평고량표（MoCA）、애발옥사사수량표（ESS）적평측。결과：①PD-RBD조주의력여계산력、시공간급집행공능、연지기억적득분명현저우PD-NRBD조화건강대조조，차이유통계학의의（균P＜0.05）；②PD-RBD조화PD-NRBD조수면효솔교건강대조조저，합병조새성수면호흡잠정저통기종합정（OSAHS）급불저퇴종합정발병솔고，차이유통계학의의（P＜0.05）；③PD-RBD조화PD-NRBD조간수면효솔급기타수면합병증차이무통계학의의（P＞0.05）。결론：파금삼병환자합병RBD여인지공능장애상관，RBD가이작위파금삼병환자인지공능장애적예측인소。
Objective: To investigate the correlation between rapid-eye-movement sleep behavior disorder (RBD) and the cognitive impairment in patients with Pakinson disease (PD).Methods: Fifty-four patients with Parkinson disease were enrolled from Neurology Department of Lishui Central Hospital from 2012 to 2013 (25 PD-RBD cases and 29 PD-NRBD cases), with 21 healthy participants as the control group. Full-night video- polysomnography (vPSG) for two nights, Uniifed Parkinson Disease Rating Scale (UPDRS-III) Questionaire, Hoehn-Yahr stage criteria, Montreal Cognitive Assessment (MoCA) and The Epworth Sleepiness Scale (ESS) were performed on all study participants.Results: The score for attention and calculation, visual-spatial and its congitive function, delayed memory in PD-RBD group were all signiifcantly lower than that in PD-NRBD group and control group (P<0.05). Sleep efficiency in both PD-RBD and PD-NRBD group were lower than that in control group, and often accompanied by obstructive sleep apnea-hypopnea syndrome and restless leg syndrome (P<0.05). There was no statistical signiifcant difference between the two PD groups (P>0.05).Conclusion: Par-kinson disease patients combined with RBD are correlated with cognitive dysfunction. RBD can be used as a predictor for cognition impairment in Parkinson disease.