CAJ | 학술논문

目的：探讨原发性高血压患者慢性压力负荷致左心室肥厚与基质金属蛋白酶3（MMP?3）、基质金属蛋白酶9（MMP?9）及金属蛋白酶组织抑制因子1（TIMP?1）血清水平的关系。方法收集原发性高血压患者140例，健康对照组132例，测定MMP?3、MMP?9和TIMP?1；行心脏彩超检查并计算左室重量指数（LVMI）。结果高血压组LVMI升高[（113.7±9.9）vs（88.3±10.4），P<0.001）]，MMP?3、MMP?9和TIMP?1增高[（488.32±100.32 vs 314.59±99.78；340.56±43.21 vs 290.15±33.98；389.16±57.53 vs 243.45±62.31；P<0.001）]。以LVMI为因变量的多元逐步回归分析显示，影响因素为年龄、SBP、MMP?3、MMP?9和TIMP?1（r2=0.78，P<0.001）。高血压组按LVMI分为高血压合并左心室肥厚组（A组）、高血压无左心室肥厚组（B组），A组SBP、MMP?3、MMP?9和TIMP?1升高[（178±31 vs 166±25）；（490.14±99.13 vs 405.56±53.12）；（340.56±43.21 vs 290.15±33.98）；（393.45±47.69 vs 301.58±39.57）；P<0.05]。结论血清MMP?3、MMP?9和TIMP?1水平是高血压合并左心室肥厚的影响因素。
목적：탐토원발성고혈압환자만성압력부하치좌심실비후여기질금속단백매3（MMP?3）、기질금속단백매9（MMP?9）급금속단백매조직억제인자1（TIMP?1）혈청수평적관계。방법수집원발성고혈압환자140례，건강대조조132례，측정MMP?3、MMP?9화TIMP?1；행심장채초검사병계산좌실중량지수（LVMI）。결과고혈압조LVMI승고[（113.7±9.9）vs（88.3±10.4），P<0.001）]，MMP?3、MMP?9화TIMP?1증고[（488.32±100.32 vs 314.59±99.78；340.56±43.21 vs 290.15±33.98；389.16±57.53 vs 243.45±62.31；P<0.001）]。이LVMI위인변량적다원축보회귀분석현시，영향인소위년령、SBP、MMP?3、MMP?9화TIMP?1（r2=0.78，P<0.001）。고혈압조안LVMI분위고혈압합병좌심실비후조（A조）、고혈압무좌심실비후조（B조），A조SBP、MMP?3、MMP?9화TIMP?1승고[（178±31 vs 166±25）；（490.14±99.13 vs 405.56±53.12）；（340.56±43.21 vs 290.15±33.98）；（393.45±47.69 vs 301.58±39.57）；P<0.05]。결론혈청MMP?3、MMP?9화TIMP?1수평시고혈압합병좌심실비후적영향인소。
Objective To investigate the relationship of matrix metalloproteinases(MMP?3 and MMP?9)and the tissue inhibitor TIMP?1 with left ventricular hypertrophy(LVH)in patients with primary hypertension. Methods Totally 140 patients with primary hypertension and 132 healthy controls were included. Matrix metalloproteinase?3(MMP?3),matrix metalloproteinase?9(MMP?9)and tissue inhibitor metalloproteinase?1 (TIMP?1)were measured. All subjects were taken echocardiography examination ,then left ventricular mass index(LVMI)was calculated. Re?sults MMP?3,MMP?9,TIMP?1(488.32±100.32 vs 314.59±99.78;340.56±43.21 vs 290.15±33.98;389.16±57.53 vs 243.45±62.31;P<0.001) and LVMI(113.7±9.9 vs 88.3±10.4,P<0.001)in patients with primary hypertension were significantly higher than those in controls. In a multiple stepwise regression analysis with LVMI as the variable,it was found that age,SBP,MMP?3,MMP?9 and TIMP?1 were main determinants for LVMI (r2=0.78,P<0.001). 3. Patients with primary hypertension were divided into two subgroups according to LVMI,i.e.,hypertension with LVH (group A)and hypertension without LVH(group B). SBP,MMP?3,MMP?9 and TIMP?1(178±31 vs 166±25;490.14±99.13 vs 405.56±53.12;340.56±43.21 vs 290.15±33.98;393.45±47.69 vs 301.58±39.57;P<0.05)of group A were significantly higher than those of group B. Conclusion MMP?3,MMP?9 and TIMP?1 are influencing factors for LVH in patients with primary hypertension.