海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
12期
1839-1841
,共3页
液基薄层细胞学%宫颈活检%宫颈病变%假阴性
液基薄層細胞學%宮頸活檢%宮頸病變%假陰性
액기박층세포학%궁경활검%궁경병변%가음성
Thinprep cytologic test (TCT)%Cervical biopsy%Cervical lesions%False-negative
目的：评估液基薄层细胞学(TCT)检测在宫颈病变临床筛查中的价值。方法选择2011年8月至2014年8月在我院就诊经TCT检测异常的宫颈病变患者700例，根据TCT检测结果分为不典型鳞状细胞和腺细胞(ASCUS)、低度及高度鳞状上皮内病变(LSIL/HSIL)、鳞癌或腺癌(SCC/AC)，并随后进行了高危型人乳头瘤病毒(HR-HPV)检测和经宫颈活检。将三种方法的检测结果进行对比。结果700例患者的TCT检测结果为ASCUS 364例(52.0%)，LSIL 256例(36.6%)，HSIL 72例(10.3%)，SCC例8例(1.1%)；宫颈活检结果为正常或炎症332例(47.4%)，宫颈上皮内瘤变Ⅰ级(CIN I)216例(30.9%)，宫颈上皮内瘤变Ⅱ级(CINⅡ)72例(10.3%)，宫颈上皮内瘤变Ⅲ级(CINⅢ)72例(10.3%)，宫颈癌(CC)8例(1.1%)；HR-HPV阳性496例(70.9%)，阴性204例(29.1%)；HR-HPV阳性率随着TCT检查分级ASCUS、LSIL、HISL的增高而增高（P<0.05）。结论 TCT与人乳头瘤病毒检测、宫颈活检符合率均较高，为宫颈病变重要的临床筛查和诊断方法，能及时发现大量的宫颈病变。
目的：評估液基薄層細胞學(TCT)檢測在宮頸病變臨床篩查中的價值。方法選擇2011年8月至2014年8月在我院就診經TCT檢測異常的宮頸病變患者700例，根據TCT檢測結果分為不典型鱗狀細胞和腺細胞(ASCUS)、低度及高度鱗狀上皮內病變(LSIL/HSIL)、鱗癌或腺癌(SCC/AC)，併隨後進行瞭高危型人乳頭瘤病毒(HR-HPV)檢測和經宮頸活檢。將三種方法的檢測結果進行對比。結果700例患者的TCT檢測結果為ASCUS 364例(52.0%)，LSIL 256例(36.6%)，HSIL 72例(10.3%)，SCC例8例(1.1%)；宮頸活檢結果為正常或炎癥332例(47.4%)，宮頸上皮內瘤變Ⅰ級(CIN I)216例(30.9%)，宮頸上皮內瘤變Ⅱ級(CINⅡ)72例(10.3%)，宮頸上皮內瘤變Ⅲ級(CINⅢ)72例(10.3%)，宮頸癌(CC)8例(1.1%)；HR-HPV暘性496例(70.9%)，陰性204例(29.1%)；HR-HPV暘性率隨著TCT檢查分級ASCUS、LSIL、HISL的增高而增高（P<0.05）。結論 TCT與人乳頭瘤病毒檢測、宮頸活檢符閤率均較高，為宮頸病變重要的臨床篩查和診斷方法，能及時髮現大量的宮頸病變。
목적：평고액기박층세포학(TCT)검측재궁경병변림상사사중적개치。방법선택2011년8월지2014년8월재아원취진경TCT검측이상적궁경병변환자700례，근거TCT검측결과분위불전형린상세포화선세포(ASCUS)、저도급고도린상상피내병변(LSIL/HSIL)、린암혹선암(SCC/AC)，병수후진행료고위형인유두류병독(HR-HPV)검측화경궁경활검。장삼충방법적검측결과진행대비。결과700례환자적TCT검측결과위ASCUS 364례(52.0%)，LSIL 256례(36.6%)，HSIL 72례(10.3%)，SCC례8례(1.1%)；궁경활검결과위정상혹염증332례(47.4%)，궁경상피내류변Ⅰ급(CIN I)216례(30.9%)，궁경상피내류변Ⅱ급(CINⅡ)72례(10.3%)，궁경상피내류변Ⅲ급(CINⅢ)72례(10.3%)，궁경암(CC)8례(1.1%)；HR-HPV양성496례(70.9%)，음성204례(29.1%)；HR-HPV양성솔수착TCT검사분급ASCUS、LSIL、HISL적증고이증고（P<0.05）。결론 TCT여인유두류병독검측、궁경활검부합솔균교고，위궁경병변중요적림상사사화진단방법，능급시발현대량적궁경병변。
Objective To evaluate the value of thinprep cytologic test (TCT) in the screening of cervical le-sions. Methods Seven hundred patients with cervical lesions showing abnormalities in TCT in our hospital from Oc-tober 2009 to September 2012 were selected. The patients were divided into three classifications according to TCT re-sults:undetermined significance atypical squamous cells and glandular cells (ASCUS), low-grade squamous intraepi-thelial lesions (LSIL) or high-grade squamous intraepithelial lesions (HSIL), squamous cell carcinoma (SCC) or ade-nocarcinoma (AC). The three groups of patients then underwent high-risk human papillomavirus (HR-HPV) testing and transvaginal cervical biopsy. The test results of the three methods were compared. Results TCT results showed 364 cases (52.0%) of ASCUS, 256 cases (36.6%) of LSIL, 72 cases (10.3%) of HSIL, and 8 cases (1.1%) of SCC cas-es. Cervical biopsy results showed 332 cases (47.4%) of normal or inflammation, 216 cases (30.9%) of cervical in-traepithelial neoplasia (CIN)Ⅰ, 72 cases (10.3%) of CINⅡ, 72 cases (10.3%) of CINⅢ, and 8 cases (1.1%) of cervi-cal cancer. According to HR-HPV testing, 496 cases (70.9%) were diagnosed as HR-HPV-positive, and 204 cases (29.1%) were diagnosed as negative. The higher the classification of TCT (ASCUS, LSIL and HISL) was, the higher the HR-HPV positive rate was (P<0.05). Conclusion TCT is of a high consistent rate with human papillomavirus testing and cervical biopsy, which could serve as an important clinical diagnostic method for cervical lesions.
