CAJ | 학술논문

目的：探讨不同基因型沙眼衣原体(CT)感染与自然流产之间的相关性。方法选择390例自然流产患者为观察组，155例正常妊娠孕妇为对照组，对比两组孕产妇CT感染率，并分析两组CT感染基因型之间的差异。结果观察组CT感染率为5.64%(22/390)，明显高于对照组的1.29%(2/155)，差异有统计学意义(P<0.05)。观察组CT感染22例(5.64%)，其中单纯D型3例(13.6%)，单纯E型7例(31.8%)，单纯F型5例(22.7%)，混合型7例(31.8%)；对照组CT感染2例(1.29%)，单纯F型1例(50%)，混合型1例(50%).两组不同基因型CT感染率比较差异无统计学意义(P>0.05)。结论沙眼衣原体感染与自然流产有着密切关系，且以E、D、F三种基因型为主，因此对于上述基因型沙眼衣原体感染孕产妇应合理使用敏感性药物进行早期干预，并加强孕期胚胎发育监测，以降低不良妊娠结局发生率。
목적：탐토불동기인형사안의원체(CT)감염여자연유산지간적상관성。방법선택390례자연유산환자위관찰조，155례정상임신잉부위대조조，대비량조잉산부CT감염솔，병분석량조CT감염기인형지간적차이。결과관찰조CT감염솔위5.64%(22/390)，명현고우대조조적1.29%(2/155)，차이유통계학의의(P<0.05)。관찰조CT감염22례(5.64%)，기중단순D형3례(13.6%)，단순E형7례(31.8%)，단순F형5례(22.7%)，혼합형7례(31.8%)；대조조CT감염2례(1.29%)，단순F형1례(50%)，혼합형1례(50%).량조불동기인형CT감염솔비교차이무통계학의의(P>0.05)。결론사안의원체감염여자연유산유착밀절관계，차이E、D、F삼충기인형위주，인차대우상술기인형사안의원체감염잉산부응합리사용민감성약물진행조기간예，병가강잉기배태발육감측，이강저불량임신결국발생솔。
Objective To discuss the correlation between different genotypes of Chlamydia trachomatis (CT) infection and spontaneous abortion. Methods A total of 390 patients with spontaneous abortion were selected as the observation group, and 155 normal pregnant women were enrolled as the control group. Then the infection rate of CT and the genotype were compared between the two groups. Results The infection rate of CT in the observation group was 5.64%(22/390), significantly higher than 1.29%(2/155) in the control group (P<0.05). Among the 22 cases of CT infection in the observation group, there were 3 cases (13.6%) of genotype with simple D type, 7 cases (31.8%) with simple E type, 5 cases (22.7%) with simple F type, and 7 cases (31.8%) with mixed infection. Among the 2 patients with CT infection in the control group, there were 1 case (50%) of genotype with simple F type and 1 case (50%) with mixed infection. There was no significant difference in the infection rate of different genotypes between the two groups (P>0.05). Conclusion There is a close relation between CT infection and spontaneous abortion, mainly infec-tion with E, D, F genotype. Pregnant women with CT infection should use drugs rationally for early intervention and strengthen the monitoring of embryonic development during pregnancy, in order to reduce the incidence of adverse pregnancy outcome.