海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
12期
1775-1777
,共3页
心肌酶谱%肌钙蛋白I%新生儿%高胆红素血症
心肌酶譜%肌鈣蛋白I%新生兒%高膽紅素血癥
심기매보%기개단백I%신생인%고담홍소혈증
Myocardial enzymes%cTnI%Newborn%Hyperbilirubinemia
目的：探讨心肌酶谱的谷草转氨酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CKMB)、乳酸脱氢酶（LDH）与肌钙蛋白I (cTnI)联合检测对高胆红素血症新生儿(HBN)的临床意义。方法选取2012年5月至2014年6月在我院接受治疗的68例HBN患儿为观察组，根据HBN分型标准将其分为轻度HBN组22例、重度HBN组24例和早产并重度HBN组22例。选择同期非HBN的健康体检者68例作为对照组。利用电化学发光免疫法检测并比较观察组和对照组患儿AST、CK、CKMB、LDH和cTnI水平。结果观察组患儿AST、CK、CKMB、LDH和cTnI水平明显高于对照组，且差异均具有统计学意义(P<0.05)；早产并重度HBN组的AST、CK、CKMB、LDH和cTnI水平明显高于轻度和重度组，差异具有统计学意义(P<0.05)。结论心肌酶谱和cTnI水平与HBN发生和发展有一定关系，联合检测心肌酶谱和cTnI对HBN筛选和诊断具有重要参考价值，但其特异性和灵敏性尚待进一步验证。
目的：探討心肌酶譜的穀草轉氨酶(AST)、肌痠激酶(CK)、肌痠激酶同工酶(CKMB)、乳痠脫氫酶（LDH）與肌鈣蛋白I (cTnI)聯閤檢測對高膽紅素血癥新生兒(HBN)的臨床意義。方法選取2012年5月至2014年6月在我院接受治療的68例HBN患兒為觀察組，根據HBN分型標準將其分為輕度HBN組22例、重度HBN組24例和早產併重度HBN組22例。選擇同期非HBN的健康體檢者68例作為對照組。利用電化學髮光免疫法檢測併比較觀察組和對照組患兒AST、CK、CKMB、LDH和cTnI水平。結果觀察組患兒AST、CK、CKMB、LDH和cTnI水平明顯高于對照組，且差異均具有統計學意義(P<0.05)；早產併重度HBN組的AST、CK、CKMB、LDH和cTnI水平明顯高于輕度和重度組，差異具有統計學意義(P<0.05)。結論心肌酶譜和cTnI水平與HBN髮生和髮展有一定關繫，聯閤檢測心肌酶譜和cTnI對HBN篩選和診斷具有重要參攷價值，但其特異性和靈敏性尚待進一步驗證。
목적：탐토심기매보적곡초전안매(AST)、기산격매(CK)、기산격매동공매(CKMB)、유산탈경매（LDH）여기개단백I (cTnI)연합검측대고담홍소혈증신생인(HBN)적림상의의。방법선취2012년5월지2014년6월재아원접수치료적68례HBN환인위관찰조，근거HBN분형표준장기분위경도HBN조22례、중도HBN조24례화조산병중도HBN조22례。선택동기비HBN적건강체검자68례작위대조조。이용전화학발광면역법검측병비교관찰조화대조조환인AST、CK、CKMB、LDH화cTnI수평。결과관찰조환인AST、CK、CKMB、LDH화cTnI수평명현고우대조조，차차이균구유통계학의의(P<0.05)；조산병중도HBN조적AST、CK、CKMB、LDH화cTnI수평명현고우경도화중도조，차이구유통계학의의(P<0.05)。결론심기매보화cTnI수평여HBN발생화발전유일정관계，연합검측심기매보화cTnI대HBN사선화진단구유중요삼고개치，단기특이성화령민성상대진일보험증。
Objective To investigate clinical significance of combined detection of myocardial enzymes (AST, CK, CKMB, LDH) and cTnI levels in hyperbilirubinemia of newborn (HBN). Methods Sixty-eight children with HBN accepted treatment in our hospital from May 2012 to June 2014 were collected as the observation group in this study, which were divided into mild HBN group with 22 cases, severe HBN group with 24 patients, premature and severe HBN group with 22 patients according to the classification criteria of HBN. Sixty-eight children who were con-sidered healthy at the same period were selected as the control group. Electrochemiluminescence immunoassay was used to detect and compare AST, CK, CKMB, LDH and cTnI levels between the observation group and the control group. Results AST, CK, CKMB, LDH and cTnI levels in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). AST, CK, CKMB, LDH and cTnI lev-els in premature birth and severe HBN group were significantly higher than in mild HBN group and severe HBN group, and the differences were statistically significant (P<0.05). Conclusion Myocardial enzymes and cTnI are cor-related with HBN. Combined detection of myocardial enzymes and cTnI has an important referential value for screen-ing and diagnosis of HBN, but its specificity and sensitivity are yet to be validated.
