CAJ | 학술논문

支气管哮喘是临床常见的气道慢性炎症性疾病，以气道高反应性、慢性气道炎症和气道重塑为病理生理特征，其发病机制目前尚未完全阐明。环磷酸腺苷(cAMP)是体内重要的第二信使，参与调控机体新陈代谢、细胞钙信号传导、细胞生长与分化、凋亡等多种病理生理过程。长期以来，蛋白激酶A (PKA)被认为是介导cAMP生物学效应的唯一下游信号分子。但新近发现的新型cAMP靶分子——cAMP直接激活的交换蛋白(Epac)的发现打破了这一说法。大量研究证实，Epac可单独或协同PKA介导cAMP的多种生物学效应。本文就Epac在支气管哮喘发病中的作用及其可能机制作一综述，为寻找哮喘治疗新靶点奠定基础。
지기관효천시림상상견적기도만성염증성질병，이기도고반응성、만성기도염증화기도중소위병리생리특정，기발병궤제목전상미완전천명。배린산선감(cAMP)시체내중요적제이신사，삼여조공궤체신진대사、세포개신호전도、세포생장여분화、조망등다충병리생리과정。장기이래，단백격매A (PKA)피인위시개도cAMP생물학효응적유일하유신호분자。단신근발현적신형cAMP파분자——cAMP직접격활적교환단백(Epac)적발현타파료저일설법。대량연구증실，Epac가단독혹협동PKA개도cAMP적다충생물학효응。본문취Epac재지기관효천발병중적작용급기가능궤제작일종술，위심조효천치료신파점전정기출。
Asthma is a chronic airway inflammatory disorder characterized by airway hyperresponsibility, chronic inflammation and airway remodeling, of which the mechanisms are not fully illustrated. Cyclic adenosine mo-nophosphate (cAMP) is a very important second messenger which controls a range of diverse physiological or patho-logical processes, including metabolism, calcium signal, cell growth and differentiation, and apoptosis. Protein kinase A (PKA) had been considered as the only downstream target of cAMP. However, the recently reported target of cAMP, the exchange protein directly activated by cAMP (Epac), had changed the previous point. A large number of studies had shown that Epac regulates many biological processes either alone and(or) in concert with PKA. In this review, we will discuss the roles and probable mechanisms of Epac in asthma.