海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
12期
1786-1787,1788
,共3页
巨细胞病毒%高血压%特异性中和抗体%几何滴度
巨細胞病毒%高血壓%特異性中和抗體%幾何滴度
거세포병독%고혈압%특이성중화항체%궤하적도
Cytomegalovirus%Hypertension%Specific neutralizing antibodies%Geometric titers
目的:探讨巨细胞病毒对人群发生高血压的影响。方法收集2011年2月至2013年6月来我院接受治疗的168例高血压患者的血液标本作为观察组,同时收集160例体检正常者的血液标本作为对照组。检测并比较两组患者血浆标本中的巨细胞病毒特异性中和抗体、巨细胞病毒特异性IgG和IgM及巨细胞病毒UL93 DNA。结果观察组患者巨细胞病毒UL93DNA、巨细胞病毒特异性IgG和IgM的阳性率分别为73.21%、70.83%和4.20%,对照组患者分别为57.50%、49.38%和2.50%,观察组患者巨细胞病毒UL93DNA和IgG的阳性率高于对照组(P<0.05),而两组间巨细胞病毒特异性IgM阳性率差异无统计学意义(P>0.05)。观察组患者血浆巨细胞病毒特异性中和抗体的几何滴度平均为(40.12±19.89),对照组为(59.96±24.85),两组患者间差异有统计学意义(P<0.05)。结论高血压患者的巨细胞病毒感染率高于健康人群,高血压患者巨细胞病毒特异性中和抗体水平降低明显,这均表明巨细胞病毒感染与人群发生高血压存在相关性。
目的:探討巨細胞病毒對人群髮生高血壓的影響。方法收集2011年2月至2013年6月來我院接受治療的168例高血壓患者的血液標本作為觀察組,同時收集160例體檢正常者的血液標本作為對照組。檢測併比較兩組患者血漿標本中的巨細胞病毒特異性中和抗體、巨細胞病毒特異性IgG和IgM及巨細胞病毒UL93 DNA。結果觀察組患者巨細胞病毒UL93DNA、巨細胞病毒特異性IgG和IgM的暘性率分彆為73.21%、70.83%和4.20%,對照組患者分彆為57.50%、49.38%和2.50%,觀察組患者巨細胞病毒UL93DNA和IgG的暘性率高于對照組(P<0.05),而兩組間巨細胞病毒特異性IgM暘性率差異無統計學意義(P>0.05)。觀察組患者血漿巨細胞病毒特異性中和抗體的幾何滴度平均為(40.12±19.89),對照組為(59.96±24.85),兩組患者間差異有統計學意義(P<0.05)。結論高血壓患者的巨細胞病毒感染率高于健康人群,高血壓患者巨細胞病毒特異性中和抗體水平降低明顯,這均錶明巨細胞病毒感染與人群髮生高血壓存在相關性。
목적:탐토거세포병독대인군발생고혈압적영향。방법수집2011년2월지2013년6월래아원접수치료적168례고혈압환자적혈액표본작위관찰조,동시수집160례체검정상자적혈액표본작위대조조。검측병비교량조환자혈장표본중적거세포병독특이성중화항체、거세포병독특이성IgG화IgM급거세포병독UL93 DNA。결과관찰조환자거세포병독UL93DNA、거세포병독특이성IgG화IgM적양성솔분별위73.21%、70.83%화4.20%,대조조환자분별위57.50%、49.38%화2.50%,관찰조환자거세포병독UL93DNA화IgG적양성솔고우대조조(P<0.05),이량조간거세포병독특이성IgM양성솔차이무통계학의의(P>0.05)。관찰조환자혈장거세포병독특이성중화항체적궤하적도평균위(40.12±19.89),대조조위(59.96±24.85),량조환자간차이유통계학의의(P<0.05)。결론고혈압환자적거세포병독감염솔고우건강인군,고혈압환자거세포병독특이성중화항체수평강저명현,저균표명거세포병독감염여인군발생고혈압존재상관성。
Objective To explore the effect of human cytomegalovirus (HCMV) on the occurrence of hyper-tension. Methods Blood samples were collected from 168 hypertensive patients (the experimental group) from Feb-ruary 2011 to June 2013 and 160 normal subjects (the control group). The HCMV specific neutralizing antibodies, HC-MV UL93 DNA, HCMV IgG and HCMV IgM of the two groups were detected and compared. Results The positive rates of HCMV UL93 DNA, HCMV IgG, HCMV IgM were 73.21%, 70.83%and 4.20%in the experimental group and 57.50%, 49.38%, 2.50%in the control group, with statistically significant differences in HCMV UL93 DNA, HC-MV IgG (P<0.05) and no statistically significant difference in HCMV IgM (P>0.05). The geometric titer of plasma HC-MV specific neutralizing antibodies was (40.12±19.89) in the experimental group and (59.96±24.85) in the control group, and the difference between the two groups was statistically significant. Conclusion The HCMV infection rate in hyper-tensive patients is higher than that in health people, and the geometric titers of plasma HCMV specific neutralizing anti-bodies is lower in hypertensive patients. There is a correlation between hypertension and HCMV infection.