中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
6期
1391-1393
,共3页
赵涓涓%张弘%汤俊%张军
趙涓涓%張弘%湯俊%張軍
조연연%장홍%탕준%장군
乳腺癌%分子亚型%肺耐药蛋白%多药耐药蛋白
乳腺癌%分子亞型%肺耐藥蛋白%多藥耐藥蛋白
유선암%분자아형%폐내약단백%다약내약단백
Breast cancer%Molecular subtype%Lung resistance protein%Multidrug resistance protein
目的 观察乳腺癌各分子亚型中肺耐药蛋白(LRP)和多药耐药蛋白(MRP)的表达,探讨其在乳腺癌表达中的意义.方法 采用免疫组织化学方法对105例乳腺癌组织进行分子分型,并检测LRP和MRP在乳腺癌各分子亚型中的表达,分析它们与各分子亚型及与雌激素受体(ER)、人类表皮生长因子受体-2(Her-2)之间的关系.结果 LRP在腺腔B型高表达(87.5％),差异有统计学意义;MRP在腺腔A型、腺腔B型、过表达型、基底样型和裸表达型乳腺癌的阳性表达率分别为62.50％、75.00％、54.55％、66.67％、70.00％,差异无统计学意义(P＞0.05).LRP与ER之间明显相关(r =0.28,P＜0.05),与Her-2无明显相关(r=0.001,P＞0.05);MRP与ER、Her-2均无明显相关(r=0.059,P＞0.05;r =0.008,P＞0.05).LRP和MRP之间呈明显正相关(r=0.309,P＜0.05).结论 LRP可预测乳腺癌尤其是腺腔B型乳腺癌的内源性耐药.
目的 觀察乳腺癌各分子亞型中肺耐藥蛋白(LRP)和多藥耐藥蛋白(MRP)的錶達,探討其在乳腺癌錶達中的意義.方法 採用免疫組織化學方法對105例乳腺癌組織進行分子分型,併檢測LRP和MRP在乳腺癌各分子亞型中的錶達,分析它們與各分子亞型及與雌激素受體(ER)、人類錶皮生長因子受體-2(Her-2)之間的關繫.結果 LRP在腺腔B型高錶達(87.5％),差異有統計學意義;MRP在腺腔A型、腺腔B型、過錶達型、基底樣型和裸錶達型乳腺癌的暘性錶達率分彆為62.50％、75.00％、54.55％、66.67％、70.00％,差異無統計學意義(P＞0.05).LRP與ER之間明顯相關(r =0.28,P＜0.05),與Her-2無明顯相關(r=0.001,P＞0.05);MRP與ER、Her-2均無明顯相關(r=0.059,P＞0.05;r =0.008,P＞0.05).LRP和MRP之間呈明顯正相關(r=0.309,P＜0.05).結論 LRP可預測乳腺癌尤其是腺腔B型乳腺癌的內源性耐藥.
목적 관찰유선암각분자아형중폐내약단백(LRP)화다약내약단백(MRP)적표체,탐토기재유선암표체중적의의.방법 채용면역조직화학방법대105례유선암조직진행분자분형,병검측LRP화MRP재유선암각분자아형중적표체,분석타문여각분자아형급여자격소수체(ER)、인류표피생장인자수체-2(Her-2)지간적관계.결과 LRP재선강B형고표체(87.5％),차이유통계학의의;MRP재선강A형、선강B형、과표체형、기저양형화라표체형유선암적양성표체솔분별위62.50％、75.00％、54.55％、66.67％、70.00％,차이무통계학의의(P＞0.05).LRP여ER지간명현상관(r =0.28,P＜0.05),여Her-2무명현상관(r=0.001,P＞0.05);MRP여ER、Her-2균무명현상관(r=0.059,P＞0.05;r =0.008,P＞0.05).LRP화MRP지간정명현정상관(r=0.309,P＜0.05).결론 LRP가예측유선암우기시선강B형유선암적내원성내약.
Objective To observe the expression of lung resistance protein (LRP) and multidrug resistance protein (MRP) in different molecular subtypes of breast cancer,and discuss their significances.Methods using immunohistochemical method in 105 cases of breast cancer for molecular classificiation,and detect the expression of LRP and MRP in different molecular subtypes by using immunohistochemical method,and analyze their relationships with the molecular subtypes,estrogen receptor (ER) and human epidermalgrowth factor receptor-2 (Her-2).Results LRP has high expression in luminal subtype B,and the difference has statistically significance.The positive expression of MRP in the luminal A,luminal B,overexpression of Her-2,basal like and naked exression breast carcinoma are 62.50％,75.00％,54.55％,66.67％,70.00％ respectively,the difference has not obvious statistical significance.The positive expression of LRP has correlation with ER positive expression (r =0.28,P ＜ 0.05),and has not obvious correlation with Her-2 positive expression (r =0.001,P ＞ 0.05).The positive expression of MRP has not obvious correlation with ER and Her-2 positive expression (r =0.059,P ＞ 0.05;r =0.008,P ＞ 0.05).The positive expression of LRP has positive correlation with MRP positive expression (r =0.309,P ＜ 0.05).Conclusion LRP can predict the endogenous drug resistance of breast cancer,especially in luminal subtype B.
