CAJ | 학술논문

目的：观察复方α-酮酸联合前列地尔注射液治疗3期慢性肾脏病（CKD）的疗效。方法将140例3期慢性肾脏病患者随机分为4组，即阴性对照组、复方α-酮酸对照组、前列地尔对照组、复方α-酮酸联合前列地尔治疗组。阴性对照组采用 CKD 常规方法进行治疗，复方α-酮酸对照组在常规治疗的基础上加入复方α-酮酸5片，每日3次口服，前列地尔对照组在常规治疗的基础上加入前列地尔10μg，入壶，静脉点滴，每日一次，联合治疗组在常规治疗的基础上加入复方α-酮酸5片，每日3次口服，前列地尔10μg 入壶，静脉点滴，每日一次。14天为1个疗程，1个疗程后观察患者血肌酐、尿素氮和内生肌酐清除率（Ccr）的变化。结果4组均可降低患者血肌酐、尿素氮和提升内生肌酐清除率（CCr ）和血红蛋白（Hb），具有统计学意义，但联合治疗组指标变化更显著（P ＜0.05）。结论复方α-酮酸联合前列地尔注射液治疗3期慢性肾脏病具有叠加效应，临床效果显著，值得在临床上推广使用。
목적：관찰복방α-동산연합전렬지이주사액치료3기만성신장병（CKD）적료효。방법장140례3기만성신장병환자수궤분위4조，즉음성대조조、복방α-동산대조조、전렬지이대조조、복방α-동산연합전렬지이치료조。음성대조조채용 CKD 상규방법진행치료，복방α-동산대조조재상규치료적기출상가입복방α-동산5편，매일3차구복，전렬지이대조조재상규치료적기출상가입전렬지이10μg，입호，정맥점적，매일일차，연합치료조재상규치료적기출상가입복방α-동산5편，매일3차구복，전렬지이10μg 입호，정맥점적，매일일차。14천위1개료정，1개료정후관찰환자혈기항、뇨소담화내생기항청제솔（Ccr）적변화。결과4조균가강저환자혈기항、뇨소담화제승내생기항청제솔（CCr ）화혈홍단백（Hb），구유통계학의의，단연합치료조지표변화경현저（P ＜0.05）。결론복방α-동산연합전렬지이주사액치료3기만성신장병구유첩가효응，림상효과현저，치득재림상상추엄사용。
Objective:To observe the effect of compound α - Ketoacid tablets combined with Alprostadil injection treat-ment of stage 3 chronic kidney disease(CKD3). Methods:140 patients with stage 3 chronic kidney disease patients were randomly divided into 4 groups,the negative control group,the compound α - Ketoacid tablets control group,the Alpros-tadil injection control group,and the compound α - Ketoacid tablets combined with Alprostadil injection treatment group. The negative control group with conventional treatment methods of CKD,the compound α - Ketoacid tablets control group on the basis of routine treatment and compound α - Ketoacid tablets 5 tablets,orally 3 times a day,the Alprostadil injec-tion control group on the basis of conventional treatment with alprostadil 10μg,into the pot,the intravenous drip,once a day,The combined treatment group on the basis of routine treatment with compound α - Ketoacid tablets 5,3 times a day orally,combined with Alprostadil injection alprostadil 10 μg into the pot,the intravenous drip,once a day. On the 14 day for 1 courses,After one courses of treatment changes in patients with serum creatinine,urea nitrogen and creatinine clear-ance rate(Ccr)were observed. Result:The serum creatinine ,urea nitrogen were decreased and endogenous creatinine clearance rate and hemoglobin were increased of 4 groups of patients,the change is statistically significant,but the com-bined treatment group was more significant changes(P < 0. 05). Conclusion:compound α - Ketoacid tablets combined with Alprostadil Injection treatment with superposition of 3 stage of chronic kidney disease,clinical effect is significant,It is worth popularizing in clinical use.