CAJ | 학술논문

目的：测定胃癌患者血清中 CK18、CEA 和 CA19-9水平并探讨其在胃癌发生发展中的作用，为胃癌的诊治提供依据。方法采用微粒子化学发光法和酶联免疫吸附（ELISA）法检测20例健康体检者、20例胃良性病变患者和40例胃癌患者血清中的 CK18、CEA、CA19-9水平，比较三种指标在血清中的变化，分析其在胃癌诊断评估中的价值。应用 SPSS22.0统计软件包进行统计学处理。结果 CK18、CEA 和 CA19-9浓度在胃癌组中显著大于其在正常组和胃良性病变组中的浓度，存在统计学差异（P ＜0.05）；CK18在腺癌组表达高于非腺癌组，差异存在统计学意义（P ＜0.05），而 CEA、CA199在腺癌组与非腺癌组无明显差异，无统计学意义（P ＞0.05）。结论血清 CK18、CEA 和 CA19-9的浓度测定对胃癌的诊断具有重要意义；监测 CK18、CEA 和 CA19-9的动态变化，对胃癌患者的疗效观察、预后评估有重要的价值。CK18在胃腺癌组表达高于胃非腺癌组，差异存在统计学意义（ P ＜0.05）。3.在联合检测中显示 CK18、CEA 和 CA19-9三个指标联合相对于单一指标效果更佳。
목적：측정위암환자혈청중 CK18、CEA 화 CA19-9수평병탐토기재위암발생발전중적작용，위위암적진치제공의거。방법채용미입자화학발광법화매련면역흡부（ELISA）법검측20례건강체검자、20례위량성병변환자화40례위암환자혈청중적 CK18、CEA、CA19-9수평，비교삼충지표재혈청중적변화，분석기재위암진단평고중적개치。응용 SPSS22.0통계연건포진행통계학처리。결과 CK18、CEA 화 CA19-9농도재위암조중현저대우기재정상조화위량성병변조중적농도，존재통계학차이（P ＜0.05）；CK18재선암조표체고우비선암조，차이존재통계학의의（P ＜0.05），이 CEA、CA199재선암조여비선암조무명현차이，무통계학의의（P ＞0.05）。결론혈청 CK18、CEA 화 CA19-9적농도측정대위암적진단구유중요의의；감측 CK18、CEA 화 CA19-9적동태변화，대위암환자적료효관찰、예후평고유중요적개치。CK18재위선암조표체고우위비선암조，차이존재통계학의의（ P ＜0.05）。3.재연합검측중현시 CK18、CEA 화 CA19-9삼개지표연합상대우단일지표효과경가。
Objective:To explore the clinical significance of serum CK18 CEA and CA19 - 9 in diagnosis of gastric cancer. Methods:CLIA(chemiluminescence immunology analysis)was used to detect the serum level of markers(CEA , CA19 - 9)in 20 cases of healthy persona,20 cases of benign diseases of stomach(gastritis ,gastric ulcer and polyp of stomach),and 40 cases of gastric cancer). ELISA was used to detect the serum level of CK18 in those people. Results:Levels of CK18 CEA and CA199 in cancer group were higher than those in healthy persona and benign diseases of stomach (P < 0. 05). Expression of CK18 in adenocarcinoma was higher than that of non adenocarcinoma group,there were signifi-cant differences(P < 0. 05),And CEA,CA199 in the adenocarcinoma group had no difference with the non cancer group, no statistical significance(P > 0. 05). Conclusion:The serum concentration of CK18,CEA and CA19 - 9 determination in diagnosis of gastric cancer has important significance . Dynamic monitoring the changes of CK18,CEA and CA19 - 9,have important value for the observation of the curative effect evaluation,prognosis of patients with gastric camcer. Expression of CK18 in adenocarcinoma was higher than that of non adenocarcinoma group,there were significant differences(P < 0. 05). The three markers(CK18,CEA ,CA19 - 9)of combined detection are better effect than single indicators .