CAJ | 학술논문

目的：探讨富氢水对重复力竭运动大鼠骨骼肌氧化应激损伤的影响。方法成年雄性 SD 大鼠100只，随机分为2组：对照组、实验组。重复运动的动物模型构建：大鼠在跑台上进行下坡跑，速度18 m/ min，坡度-16度，大强度重复运动（力竭运动）。设立实验组、对照组（实验组运动前30min 与运动后即刻口服各10ml 体重富氢水；对照组相同时间口服同剂量生理盐水），进行同样的重复力竭运动，在同一时间点分别对对照组、实验组在大强度重复运动（力竭运动）后取股四头肌，同时对实验组大鼠进行治疗量富氢水喂养，考察富氢水对重复运动下大鼠骨骼肌微损伤氧化应激损伤的影响作用，观察对照组、实验组大强度运动（重复运动）下大鼠骨骼肌超微结构变异进行研究。结果补充富氢水后重复运动训练下大鼠骨骼肌超微结构变异研究表明：利用透射电镜对补充富氢水后大鼠进行相同的重复运动（力竭运动）后，该过程中骨骼肌超微结构变化程度看出大鼠股四头肌的微损伤有显著改善，但是仍表现为肌原纤维排列不规则，肌节不完整，Z 线变细，肌丝卷曲等。结论大强度运动下骨骼肌超微结构图谱变异与骨骼肌微损伤或者疲劳存在一定的适应性机制，同时对补充富氢水过程中可带来一定的修复机制，富氢水对重复力竭运动大鼠骨骼肌氧化应激损伤具有保护作用。
목적：탐토부경수대중복력갈운동대서골격기양화응격손상적영향。방법성년웅성 SD 대서100지，수궤분위2조：대조조、실험조。중복운동적동물모형구건：대서재포태상진행하파포，속도18 m/ min，파도-16도，대강도중복운동（력갈운동）。설립실험조、대조조（실험조운동전30min 여운동후즉각구복각10ml 체중부경수；대조조상동시간구복동제량생리염수），진행동양적중복력갈운동，재동일시간점분별대대조조、실험조재대강도중복운동（력갈운동）후취고사두기，동시대실험조대서진행치료량부경수위양，고찰부경수대중복운동하대서골격기미손상양화응격손상적영향작용，관찰대조조、실험조대강도운동（중복운동）하대서골격기초미결구변이진행연구。결과보충부경수후중복운동훈련하대서골격기초미결구변이연구표명：이용투사전경대보충부경수후대서진행상동적중복운동（력갈운동）후，해과정중골격기초미결구변화정도간출대서고사두기적미손상유현저개선，단시잉표현위기원섬유배렬불규칙，기절불완정，Z 선변세，기사권곡등。결론대강도운동하골격기초미결구도보변이여골격기미손상혹자피로존재일정적괄응성궤제，동시대보충부경수과정중가대래일정적수복궤제，부경수대중복력갈운동대서골격기양화응격손상구유보호작용。
Objective:To investigate the hydrogen - rich water on skeletal muscle oxidative stress in rats after exhaus-tive exercise was repeated injury. Methods:100 adult male SD rats were randomly divided into 2 groups:control group,the experimental group. Construction of an animal model of repetitive motion:bench rats ran downhill running,speed 18 m /min,the slope of - 16 degrees,repeated high - intensity exercise(exhaustive exercise). The establishment of the experi-mental group(each 10ml oral immediate weight hydrogen - rich water before and after the experimental group sports and ex-ercise 30min;the same time the control group was treated with the same dose of saline)group,and the same was repeated exhaustive exercise,respectively,at the same time control group,the experimental group were quadriceps strength after re-petitive motion(exhaustive exercise),while the experimental group were treated rats fed the amount of hydrogen - rich wa-ter to investigate hydrogen - rich water damage in rat skeletal muscle micro - oxidation under repetitive motion the influence of stress injury observed in the control group,the experimental group of high - intensity exercise(repetitive motion)in rat skeletal muscle ultrastructure variation research. Variability of the results of rat skeletal muscle ultrastructure complementa-ry hydrogen - rich water after repeated studies have shown that exercise training:the use of transmission electron microsco-py after complementary hydrogen - rich water rats subjected to the same repetitive motion(exhaustive exercise),the skele-tal muscle in the process over the extent of structural changes in the micro - micro quadriceps injury in rats seen a signifi-cant improvement,but still showed myofibrils irregular,incomplete sarcomere,Z thinning,muscle wire curling. Patterns of variation in skeletal muscle ultrastructure and skeletal muscle damage or fatigue micro - adaptive mechanisms exist certain conclusions high intensity exercise,while the complementary process of hydrogen - rich water can bring certain repair mechanisms,hydrogen - rich water sports on repeat Exhaustive oxidative stress in rat skeletal muscle injury in rats.