CAJ | 학술논문

目的：观察百白破疫苗和麻疹减毒活疫苗同时免疫小鼠后的抗体应答和不良反应。方法用百白破疫苗和麻疹减毒活疫苗皮下注射免疫小鼠，于末次免疫后10 d取血清，用ELISA间接法检测特异性IgG抗体水平，比较上述两种疫苗同时免疫与单独免疫小鼠后特异性IgG的产生水平，并观察其发生不良反应的差异。结果同时免疫两种疫苗的实验组白喉抗体效价显著低于单独免疫的实验组，而前者不良反应发生率显著高于后者，差异有统计学意义(P<0.05)。结论两种疫苗同时接种与单独接种比较，抗体应答水平较低，安全性较差，最好不要同时接种。
목적：관찰백백파역묘화마진감독활역묘동시면역소서후적항체응답화불량반응。방법용백백파역묘화마진감독활역묘피하주사면역소서，우말차면역후10 d취혈청，용ELISA간접법검측특이성IgG항체수평，비교상술량충역묘동시면역여단독면역소서후특이성IgG적산생수평，병관찰기발생불량반응적차이。결과동시면역량충역묘적실험조백후항체효개현저저우단독면역적실험조，이전자불량반응발생솔현저고우후자，차이유통계학의의(P<0.05)。결론량충역묘동시접충여단독접충비교，항체응답수평교저，안전성교차，최호불요동시접충。
Objective To investigate the antibody response and adverse reactions of mice after they were im-munized by DPT and measles vaccine. Methods The mice were immunized subcutaneously by DPT and measles vaccine at the same time in different parts. Serum samples were taken at 10 days after the last immunization. Specific IgG antibody levels were detected by indirect ELISA. The levels of applying the two vaccines separately and simulta-neously were compared, and the differences of adverse reactions were observed. Results Antibody titers of applying the two vaccines simultaneously were significantly lower than those applying the two vaccines separately, and the for-mer had significantly higher incidence of adverse reactions (P<0.05). Conclusion It is recommended to vaccinate vaccines separately, because simultaneous vaccination may cause lower level of antibody response and poor security.