CAJ | 학술논문

肝素原（heparosan）是某些细菌荚膜中多糖骨架的二糖重复单位，同时也是肝素和硫酸乙酰肝素的生物合成前体。以发酵获得的肝素原为前体骨架多糖，采用化学或生物修饰生产肝素及其类似物是目前非动物来源肝素生产的研究热点。近来发现，肝素原还可作为良好的药物载体，具有调节肠道菌群等作用。本文对其应用研究作一综述。
간소원（heparosan）시모사세균협막중다당골가적이당중복단위，동시야시간소화류산을선간소적생물합성전체。이발효획득적간소원위전체골가다당，채용화학혹생물수식생산간소급기유사물시목전비동물래원간소생산적연구열점。근래발현，간소원환가작위량호적약물재체，구유조절장도균군등작용。본문대기응용연구작일종술。
Heparosan is a polysaccharide found in the capsule of certain bacteria ,as well as the biosynthesis precursor of heparin and heparan sulfate of animals .Now researches mainly focus on the non‐animal origin produc‐tion of heparin which employs chemical or biological modifications and takes the heparosan from fermentation as precursor .It has been recently found that heparosan can serve as a good drug carrier and regulate the intestinal flora and so on .This article reviews the latest progress of its application .