河南科技大学学报（医学版）
河南科技大學學報（醫學版）
하남과기대학학보（의학판）
JOURNAL OF HENAN UNIVERSITY OF SCIENCE & TECHNOLOGY(MEDICAL SCIENCE)
2015年
2期
84-86
,共3页
血必净%重度颅脑外伤%感染发生率%T 淋巴细胞亚群
血必淨%重度顱腦外傷%感染髮生率%T 淋巴細胞亞群
혈필정%중도로뇌외상%감염발생솔%T 림파세포아군
Xuebijing injection%craniocerebral trauma%incidence of infection%T lymphocyte subsets
目的：研究血必净对重度颅脑损伤患者感染发生率及外周血 T 淋巴细胞亚群的影响。方法选择我院2013年10月至2014年10月收治的96例重度颅脑外伤患者为观察对象，以数字法随机分成观察组与对照组各48例。对照组采用常规方法治疗，观察组加用血必净注射液。对比两组感染发生率，分析患者 T 淋巴细胞亚群的分布。结果观察组在手术部位、肺部、呼吸道和泌尿系统发生感染率均显著低于对照组，观察组总感染率也显著低于对照组。两组患者入院第1天，CD4＋、CD8＋和 CD4＋／CD8＋比值无明显差异；治疗后第3天、第5天，CD4＋显著高于对照组，CD8＋低于对照组，CD4＋／CD8＋显著高于对照组；两组 CD4＋、CD8＋和 CD4＋／CD8＋比值均较入院第1天有回升，且观察组回升更为明显。观察组治疗后第3天和第5天免疫球蛋白的 IgG、IgA、IgM指标均高于对照组。治疗后第5天，观察组免疫球蛋白的 IgG、IgA、IgM指标均显著高于对照组。结论加用血必净治疗重度颅脑外伤可提高患者机体免疫功能，较快改善 T 淋巴细胞亚群，降低感染发生率。
目的：研究血必淨對重度顱腦損傷患者感染髮生率及外週血 T 淋巴細胞亞群的影響。方法選擇我院2013年10月至2014年10月收治的96例重度顱腦外傷患者為觀察對象，以數字法隨機分成觀察組與對照組各48例。對照組採用常規方法治療，觀察組加用血必淨註射液。對比兩組感染髮生率，分析患者 T 淋巴細胞亞群的分佈。結果觀察組在手術部位、肺部、呼吸道和泌尿繫統髮生感染率均顯著低于對照組，觀察組總感染率也顯著低于對照組。兩組患者入院第1天，CD4＋、CD8＋和 CD4＋／CD8＋比值無明顯差異；治療後第3天、第5天，CD4＋顯著高于對照組，CD8＋低于對照組，CD4＋／CD8＋顯著高于對照組；兩組 CD4＋、CD8＋和 CD4＋／CD8＋比值均較入院第1天有迴升，且觀察組迴升更為明顯。觀察組治療後第3天和第5天免疫毬蛋白的 IgG、IgA、IgM指標均高于對照組。治療後第5天，觀察組免疫毬蛋白的 IgG、IgA、IgM指標均顯著高于對照組。結論加用血必淨治療重度顱腦外傷可提高患者機體免疫功能，較快改善 T 淋巴細胞亞群，降低感染髮生率。
목적：연구혈필정대중도로뇌손상환자감염발생솔급외주혈 T 림파세포아군적영향。방법선택아원2013년10월지2014년10월수치적96례중도로뇌외상환자위관찰대상，이수자법수궤분성관찰조여대조조각48례。대조조채용상규방법치료，관찰조가용혈필정주사액。대비량조감염발생솔，분석환자 T 림파세포아군적분포。결과관찰조재수술부위、폐부、호흡도화비뇨계통발생감염솔균현저저우대조조，관찰조총감염솔야현저저우대조조。량조환자입원제1천，CD4＋、CD8＋화 CD4＋／CD8＋비치무명현차이；치료후제3천、제5천，CD4＋현저고우대조조，CD8＋저우대조조，CD4＋／CD8＋현저고우대조조；량조 CD4＋、CD8＋화 CD4＋／CD8＋비치균교입원제1천유회승，차관찰조회승경위명현。관찰조치료후제3천화제5천면역구단백적 IgG、IgA、IgM지표균고우대조조。치료후제5천，관찰조면역구단백적 IgG、IgA、IgM지표균현저고우대조조。결론가용혈필정치료중도로뇌외상가제고환자궤체면역공능，교쾌개선 T 림파세포아군，강저감염발생솔。
Objective To study influence of Xuebijing Injection for the infection incidence of patients with severe craniocerebral trauma and the expression of peripheral blood T lymphocyte subsets. Methods From October 2013 to October 2014,96 patients with severe craniocerebral trauma treated in our hospital. They were in digital method randomly divided into observation group (48 cases)and control group (48 cases).Control group was given conventional methods of treatment,observation group on the basis of routine treatment plus Xuebijing injection. Comparing two groups of patients with postoperative incidence of infection,and exploring the blood will be a net for the expression of peripheral blood T lymphocyte subsets in patients with influence. Results The observation group of surgical site infection, lung infections, respiratory infections and urinary tract infections were significantly lower than the control group.Observation group infection rate was also significantly lower than the control group.Two groups of patients in hospital day 1 ,CD4 +,CD8 + and CD4 +/CD8 + ratio had no obvious difference.CD4 + 3 and 5 days after treatment were significantly higher than that of control group,CD8 + were significantly lower than the control group,CD4 +/CD8 +were significantly higher than the control group.Observation group of CD4 +,CD8 + and CD4 +/CD8 +ratio were admitted to hospital in 1 day had recovered,and the observation group picked up more apparent. Observation group 3 and 5 days after treatment in patients with immunoglobulin IgG,IgA and IgM indicators were higher than the control group.5 days after treatment,observation group of patients with immunoglobulin IgG,IgA,IgM index were significantly higher than the control group. Conclusion On the basis of conventional treatment of severe craniocerebral trauma patients treated with Xuebijing injection can improve the body′s immune function,can rapidly improve the T lymphocyte subgroup.
